TRIHEPTANOIN
TRIHEPTANOIN Basic information
- Product Name:
- TRIHEPTANOIN
- Synonyms:
-
- glyceroltriheptanoate
- Glycerol-triheptanoate-
- Glyceroltriheptanoate,1,2,3-propanetriylester
- GLYCERINETRIHEPTANOATE
- triheptylin
- trioenanthoin
- GLYCERYL TRIHEPTANOATE
- GLYCEROL TRIOENANTHATE
- CAS:
- 620-67-7
- MF:
- C24H44O6
- MW:
- 428.6
- EINECS:
- 210-647-2
- Product Categories:
-
- viscosity controlling agents
- surfactant
- Mol File:
- 620-67-7.mol
TRIHEPTANOIN Chemical Properties
- Boiling point:
- 200 °C(Press: 1 Torr)
- Density
- 0.966 g/mL at 20 °C(lit.)
- refractive index
- n20/D 1.444
- storage temp.
- Store at -20°C, protect from light
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
- form
- A liquid
- color
- Colorless to light yellow
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChI
- InChI=1S/C24H44O6/c1-4-7-10-13-16-22(25)28-19-21(30-24(27)18-15-12-9-6-3)20-29-23(26)17-14-11-8-5-2/h21H,4-20H2,1-3H3
- InChIKey
- PJHKBYALYHRYSK-UHFFFAOYSA-N
- SMILES
- C(OC(=O)CCCCCC)C(OC(=O)CCCCCC)COC(=O)CCCCCC
- LogP
- 8.86 at 22℃
- CAS DataBase Reference
- 620-67-7
- EPA Substance Registry System
- Heptanoic acid, 1,1',1''-(1,2,3-propanetriyl) ester (620-67-7)
MSDS
- Language:English Provider:SigmaAldrich
TRIHEPTANOIN Usage And Synthesis
Chemical Properties
colourless liquid
Uses
triheptanoin is a triglyceride that acts as a surfactant and skinconditioning agent, it also helps increase product viscosity. often used in cleansers, face and neck products, moisturizers and lipsticks.
Flammability and Explosibility
Non flammable
Biological Activity
Triheptanoin is a triglyceride with 3 molar eq. of saturated heptanoic acid (C7:0). The even-chain FA does not occur naturally and is able to bypass metabolic block induced by enzyme deficiency and to replenish reduced tricarboxylic acid/TCA-cycle (Krebs cycle or citric acid cycle/CAC) intermediates (anaplerosis) in vivo.
in vivo
In long-chain fatty acid oxidation disorders (LC-FAOD), Triheptanoin is used as an anaplerotic compound, acting as a source of calories and fatty acids to bypass the LC-FAOD enzyme deficiencies[1].
Triheptanoin can be used for the research of ataxia-telangiectasia (A-T)[2].
Triheptanoin functions as an anaplerotic agent replenishing tricarboxylic acid (TCA) cycle intermediates by metabolism to heptanoate (C7) and subsequently acetyl-CoA and propionyl-CoA that feed into the TCA cycle to supply energy[2].
Triheptanoin mitigates brain ATP depletion and mitochondrial dysfunction, including respiration and redox balance in a mouse model of Alzheimer's disease, supporting the energy failure hypothesis for that disorder[2].
Triheptanoin (Mice were treated with Triheptanoin (35E%) for 10 days prior to pilocarpine injection to induce status epilepticus) preserved mitochondrial functions in the hippocampal formations of pilocarpine-induced status epilepticus (SE) mice[3].
| Animal Model: | 7-8 week old male CD1 (35-40 g)[3] |
| Dosage: | 35E% oral Triheptanoin was mixed into mouse chow |
| Administration: | Given 35E% Triheptanoin treatment 10 days prior to SE induction |
| Result: | Preserved mitochondrial functions in SE mice. |
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