3-DEAZA-2'-DEOXYADENOSINE Chemical Properties

Melting point:

208-209 °C

Boiling point:

617.7±65.0 °C(Predicted)

Density 

1.75±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 5 mg/ml; DMSO: 20 mg/ml; PBS (pH 7.2): 10 mg/ml

form 

A crystalline solid

pka

13.88±0.60(Predicted)

3-DEAZA-2'-DEOXYADENOSINE Usage And Synthesis

Uses

3-Deaza-2 '-deoxyadenosine is a nucleoside analog synthesized from 2' -deoxyadenosine. 3-Deaza-2 '-deoxyadenosine inhibits RNA synthesis by binding to ribose fragments of ribonucleotides, thereby preventing the formation of enzyme-substrate complexes, thereby preventing chain elongation, It can also inhibit DNA synthesis by binding deoxyribose fragments of DNA and preventing DNA polymerase from adding nucleotides to the growth chain. 3-Deaza-2 '-deoxyadenosine has antiviral activity[1][2].

References

[1] Hendrickson CL, et al. Probing minor groove recognition contacts by DNA polymerases and reverse transcriptases using 3-deaza-2'-deoxyadenosine. Nucleic Acids Res. 2004 Apr 23;32(7):2241-50. DOI:10.1093/nar/gkh542
[2] Cristalli G, et al. Synthesis and biological evaluation of N6-cycloalkyl derivatives of 1-deazaadenine nucleosides: a new class of anti-human immunodeficiency virus agents. J Med Chem. 1995 Sep 29;38(20):4019-25. DOI:10.1021/jm00020a017

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