ANTIBIOTIC MYC-8003
ANTIBIOTIC MYC-8003 Basic information
- Product Name:
- ANTIBIOTIC MYC-8003
- Synonyms:
-
- KIRROMYCIN
- ANTIBIOTIC MYC-8003
- MOCIMYCIN
- delvomycin
- myc8003
- kirromycin from streptomyces collinus
- NSC 316094
- Stereoisomer of N-[7-[5-[7-(1,2-dihydro-4-hydroxy-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1,3,5-heptatrienyl]tetrahydro-3,4-dihydroxy-2-furanyl]-6-methoxy-5-methyl-2,4-octadienyl]-alpha-ethyltetrahydro-2,3,4-trihydroxy-5,5-dimethyl-6-(1,3-pentadienyl)-2H-pyran-2-acetamide
- CAS:
- 50935-71-2
- MF:
- C43H60N2O12
- MW:
- 796.94
- EINECS:
- 2568599
- Mol File:
- 50935-71-2.mol
ANTIBIOTIC MYC-8003 Chemical Properties
- alpha
- D22 -60° (c = 1 in methanol)
- storage temp.
- −20°C
- solubility
- methanol: soluble1.90-2.10mg/mL, clear, yellow
- form
- A solid
- color
- yellow
Safety Information
- Risk Statements
- 36/37/38-66
- Safety Statements
- 26-36
- WGK Germany
- -
- RTECS
- QA2805000
- Toxicity
- LD50 i.p. in mice: >1000 mg/kg (DE 2140674)
MSDS
- Language:English Provider:SigmaAldrich
ANTIBIOTIC MYC-8003 Usage And Synthesis
Description
Kirromycin is an antibiotic originally isolated from Streptomyces and an inhibitor of protein biosynthesis. It inhibits isoleucine incorporation, polyphenylalanine synthesis, and growth of B. brevis. Kirromycin inhibits elongation factor Tu-dependent peptidyl transfer activity in E. coli.
Uses
Kirromycin from Streptomyces collinus is an antibiotic inhibitor of protein synthesis.
Definition
ChEBI: Mocimycin is a C-glycosyl compound.
storage
+4°C
References
[1] H. WOLF K. N H Z?hner. Kirromycin, an inhibitor of the 30 S ribosomal subunits function[J]. FEBS Letters, 1972, 21 3: Pages 347-350. DOI: 10.1016/0014-5793(72)80199-6
[2] H WOLF A P G Chinali. Kirromycin, an inhibitor of protein biosynthesis that acts on elongation factor Tu.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1974, 71 12: 4910-4914. DOI: 10.1073/pnas.71.12.4910
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