Ribostamycin sulfate Chemical Properties

Melting point:

175-180 C

alpha 

D20 +39° (c = 1)

Flash point:

>110°(230°F)

storage temp. 

Inert atmosphere,2-8°C

solubility 

H2O: soluble50mg/mL

form 

powder

color 

White to Off-White

Water Solubility 

Soluble in water

Merck 

14,8206

Stability:

Hygroscopic

InChIKey

RTCDDYYZMGGHOE-CARKYZAMNA-N

SMILES

OS(O)(=O)=O.NC[C@@H]1O[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O)[C@@H]2O[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)[C@@H](N)[C@H](O)[C@H]1O

Safety Information

Hazard Codes 

T,Xi

Risk Statements 

61-20/21/22-36/38

Safety Statements 

53-22-36/37/39-45-37/39-26

WGK Germany 

3

RTECS 

WK2300000

HS Code 

2941.90.1010

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Repr. 1B

Toxicity

LD50 i.v. in mice: 225 mg/kg (Shomura)

Ribostamycin sulfate Usage And Synthesis

Uses

Antibacterial;Ribosomal protein synthesis inhibitor

Uses

Ribostamycin is a broad-spectrum antimicrobial isolated from Streptomyces ribosifidicus. It is used in pharmacokinetic and nephrotoxicity studies.

Definition

ChEBI: An aminoglycoside sulfate salt resulting from the reaction of ribostamycin with sulfuric acid.

Biological Activity

Aminoglycosides, such as ribostamycin, bind to the bacterial 30S and 50S ribosomal subunit, which inhibits the translocation of the peptidyl-tRNA from the A-site to the P-site. This causes misreading of mRNA which makes bacteria unable to make essential proteins. It also inhibits the chaperone activity of protein disulfide isomerase (PDI).

Synthesis

Preparation of high-purity ribostamycin sulfate:
1. The resolving solution is acidified and diluted.
2. Loaded onto an ion-exchange column, washed with water.
3. Eluted with ammonia, collecting fractions before optical rotation reaches "0".
4. The eluate is concentrated by nanofiltration and then by steam thin-film evaporation.
5. The concentrate is treated with charcoal and spray-dried.

Ribostamycin sulfate(53797-35-6)Related Product Information

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• MICRONOMICIN SULFATE
• sulfate
• 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE