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Spectinomycin sulfate tetrahydrate

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Spectinomycin sulfate tetrahydrate Basic information

Product Name:
Spectinomycin sulfate tetrahydrate
Synonyms:
  • SPECTINOMYCINHCL
  • Actinospectacin, tetrahydrate, sulfate
  • Spectinomycin, tetrahydrate, sulfate
  • Trobicin sulfate
  • SpectinoMycin sulfate tetrahydrate CGMP/FDA
  • Spectinomycin sulfate tetrahydrate
  • SPECTINOMYCIN SULFATE
  • SPECTINOMYCIN SULPHATE
CAS:
64058-48-6
MF:
C14H26N2O11S
MW:
430.43
EINECS:
613-422-0
Product Categories:
  • API
Mol File:
64058-48-6.mol
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Spectinomycin sulfate tetrahydrate Chemical Properties

Melting point:
~185° (dec)
alpha 
D25 +17.0° (c = 1 in water)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Water (Slightly)
pka
pKa1 7.00, pKa2 8.75(at 25℃)
color 
White
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Spectinomycin sulfate tetrahydrate Usage And Synthesis

Uses

Spectinomycin Sulfate Tetrahydrate (cas# 64058-48-6) is a compound useful in organic synthesis.

in vivo

Spectinomycin dihydrochloride pentahydrate (20 mg/kg; i.m.; 20-100 mg/kg; 9 d) shows the safety in healthy chicks[4].
Spectinomycin dihydrochloride pentahydrate (10 mg/kg; i.v.; single dose) has the major elimination pathway by renal excretion, approximately 55% is excreted into the urine in unchanged form[5].
Pharmacokinetics of Spectinomycin dihydrochloride pentahydrate in Rat[5]

ParameterC0 (μg/mL)AUC0-∞ (μg?h/mL)Vd (L/kg)CL (L/h/kg)MRT (h)T1/2α (h)T1/2β (h)T1/2γ (h)feCLrenal (L/h/kg)Eratio
Non atrioventricular analysis44.316.80.7560.6020.757///0.5530.3591.00
Three-compartment model37.815.70.7470.6491.11/0.2370.75419.5//
Animal Model:Arbor Acres plus broiler chicks (15-day-old)[4]
Dosage:20 mg/kg, 60 mg/kg, 100 mg/kg
Administration:Intramuscular injection (chest muscles); 9 days
Result:Showed biosecurity of 20 mg/kg by complete blood count, biochemical parameters, histopathological, clinical signs, body weight gain, and feed conversion ratio (FCR).
Resulted minor toxicity of 60 mg/kg.

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hbeixys2001@163.com
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