METHYL 7-BROMO-1-BENZOTHIOPHENE-2-CARBOXYLATE Chemical Properties

Melting point:

99-102°C

storage temp. 

2-8°C(protect from light)

form 

solid

color 

Off-white

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2934999090

METHYL 7-BROMO-1-BENZOTHIOPHENE-2-CARBOXYLATE Usage And Synthesis

Synthesis

GENERAL METHOD: Under stirring conditions, 3-bromo-2-fluorobenzaldehyde (9.90 mmol) was dissolved in DMF (20 mL) and methyl mercaptoacetate (10.9 mmol) and potassium carbonate (39.6 mmol) were added sequentially. The reaction mixture was stirred continuously at 60 °C for 15 hours. After completion of the reaction, the DMF solvent was removed by distillation under reduced pressure. Water (50 mL) was added to the residue, which was subsequently extracted with ethyl acetate (2 x 40 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to remove the solvent to afford the target product, methyl 7-bromobenzo[b]thiophene-2-carboxylate.

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 125, p. 538 - 550
[2] Patent: KR2015/117318, 2015, A. Location in patent: Paragraph 0181; 0187; 0188; 0189

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