N-(4-Nitrophenyl)propionamide Chemical Properties

Melting point:

182 °C

Boiling point:

411.7±28.0 °C(Predicted)

Density 

1.287±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

13.91±0.70(Predicted)

Safety Information

HS Code 

2924297099

N-(4-Nitrophenyl)propionamide Usage And Synthesis

Synthesis

General procedure for the synthesis of p-nitropropionanilide from propionyl chloride and 4-nitroanilide: To a solution of 4-nitroanilide (7.5 mmol, 1.04 g) in dichloromethane (30 mL) was slowly added propionyl chloride (7.5 mmol, 0.70 mL). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was filtered and the filtrate was concentrated under reduced pressure by rotary evaporator to remove the solvent. The crude product was washed with hexane (10 mL) to remove impurities. Finally, the product was dried under vacuum to afford the target compound N-(4-nitrophenyl)propionamide in white powder form in a yield of 0.38 g (26% yield).

References

[1] Dalton Transactions, 2014, vol. 43, # 23, p. 8888 - 8893
[2] Patent: US2014/228579, 2014, A1. Location in patent: Paragraph 0155
[3] Pest Management Science, 2000, vol. 56, # 7, p. 607 - 614
[4] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 23, p. 10034 - 10042
[5] Patent: WO2010/129053, 2010, A2. Location in patent: Page/Page column 112-113

N-(4-Nitrophenyl)propionamide(4850-93-5)Related Product Information

• Propionyl bromide
• Ethyl propionylacetate
• N-Methyl-4-nitroaniline
• L-Alanyl-L-Glutamine
• 4'-Nitroacetanilide
• PICROLONIC ACID
• N-Benzoyl-DL-arginine-4-nitroanilide hydrochloride
• SUC-ALA-ALA-ALA-PNA
• L-Glutamic acid γ-(4-nitroanilide)
• 4-Chloro-2-nitroaniline
• 4-Nitroaniline
• 2-Nitroaniline
• NITROGEN DIOXIDE
• H-PHE-PNA HCL
• Z-PHE-PNA
• (S)-2-amino-N-(4-nitrophenyl)propionamide hydrochloride
• PROPIONANILIDE
• PYR-PNA