Befloxatone
Befloxatone Basic information
- Product Name:
- Befloxatone
- Synonyms:
-
- Befloxatone
- (R)-5-(methoxymethyl)-3-(4-((R)-4,4,4-trifluoro-3-hydroxybutoxy)phenyl)oxazolidin-2-one
- 2-Oxazolidinone, 5-(methoxymethyl)-3-[4-[(3R)-4,4,4-trifluoro-3-hydroxybutoxy]phenyl]-, (5R)-
- 503
- MD 370503
- MD-370
- MD370503
- MD-370503
- CAS:
- 134564-82-2
- MF:
- C15H18F3NO5
- MW:
- 349.3
- Mol File:
- 134564-82-2.mol
Befloxatone Chemical Properties
- Melting point:
- 101°
- alpha
- D20 -11.5° (c = 1 in methylene chloride)
- Boiling point:
- 447.3±45.0 °C(Predicted)
- Density
- 1.326±0.06 g/cm3(Predicted)
- pka
- 12.13±0.20(Predicted)
Befloxatone Usage And Synthesis
Uses
Befloxatone is a selective and reversible inhibitor of monoamine oxidase A. A third line agent for the treatment of resistant depression.
in vivo
Befloxatone (0.75 mg/kg; i.p.; single dose) increases tissue levels of monoamines and decreases levels of their deaminating metabolites in rats[1].
Befloxatone (1 mg/kg; i.p.; single dose) induces elevated levels of dopamine and corticonorepinephrine in the extracellular striatum of rats, but not elevates levels of corticoserotonin[1].
Befloxatone (0.03-0.3 mg/kg; p.o.; single dose) effectively inhibits the firing rate of serotonergic neurons and partially reduces the firing of norepinephric neurons, but had no effect on the firing of dopaminergic neurons in rats[1].
Befloxatone (1.5 mg/kg; p.o.; single dose) does not enhance the pressor effect of the central active dose of oral tyramine and has a broad safety profile in rats[1].
IC 50
MAO-A: 4 nM (IC50); MAO-B: 300 nM (IC50)
Befloxatone(134564-82-2)Related Product Information
- (R)-5-(HYDROXYMETHYL)-3-METHYLOXAZOLIDIN-2-ONE
- 5-HYDROXYMETHYL-3-(4-METHOXYPHENYL)-2-OXAZOLIDINONE
- METHYL N-(4-METHOXYPHENYL)CARBAMATE
- (R)-5-(HYDROXYMETHYL)-3-PHENYLOXAZOLIDIN-2-ONE
- Befloxatone
- (R)-5-METHOXYMETHYL-2-OXAZOLIDINONE
- 3-PHENYL-2-OXAZOLIDINONE
- (4-METHOXY-PHENYL)-CARBAMIC ACID ETHYL ESTER
- (R)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL