parsalmide
parsalmide Basic information
- Product Name:
- parsalmide
- Synonyms:
-
- 5-Amino-N-butyl-2-(2-propynyloxy)benzamide
- MY-41-6
- Parsal
- 5-Amino-N-butyl-2-(2-propyn-1-yloxy)benzamide
- parsalmide
- Benzamide, 5-amino-N-butyl-2-(2-propyn-1-yloxy)-
- CAS:
- 30653-83-9
- MF:
- C14H18N2O2
- MW:
- 246.3
- EINECS:
- 250-274-2
- Mol File:
- 30653-83-9.mol
parsalmide Chemical Properties
- Melting point:
- 83-85℃
- Boiling point:
- 389.31°C (rough estimate)
- Density
- 1.107
- refractive index
- 1.5500 (estimate)
- pka
- pKa (aq soln, 20°) 4.6 ±0.03
parsalmide Usage And Synthesis
Originator
Parsalmide,Shanghai Lansheng Corporation
Definition
ChEBI: Parsalmide is a member of benzamides.
Manufacturing Process
5-Acetylamino-2-acetoxybenzoyl chloride was obtained by reaction of 5acetylamino-2-acetoxy-benzoic acid with thionylchloride.
5-Acetylamino-N-butyl-2-hydroxybenzamide was produced in the result of treatment of 5-acetylamino-2-acetoxybenzoyl chloride with butylamine in the
presence of sodium hydroxide
5-Acetamino-N-(n-butyl)-2-propargyloxybenzamide was obtained by reaction of 5-acetylamino-N-butyl-2-hydroxybenzamide with propargylbromide in the presence of sodium, isopropyl alcohol and sulfuric acid.
28.8 g (0.1 mole) 5-acetamino-N-(n-butyl)-2-propargyloxybenzamide in 320 ml of 4 N sulfuric acid was heated, under stirring, at 90°-95°C for 2 h. The clear solution was cooled and its pH adjusted to 1 with 1 N NaOH; after filtering, further alkali was subsequently added until a pH of 10 was obtained. At this point the product was separated by filtration and recrystallized from ethanol at 60°C to give 16.6 g (a yield of 68%) of chromatographically pure 5-amino-N-(n-hutyl)-2-propargyloxybenzamide; melting point 85°-87°C.
Therapeutic Function
Muscle relaxant, Antiinflammatory, Analgesic