Davercin Chemical Properties

Melting point:

>135°C (dec.)

Boiling point:

859.8±65.0 °C(Predicted)

Density 

1.22±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)

pka

13.49±0.70(Predicted)

form 

Solid

color 

White

Safety Information

Toxicity

LD50 oral in rat: 5800mg/kg

Davercin Usage And Synthesis

Description

Davercin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It has broad-spectrum activity against various Gram-positive and Gram-negative bacteria (MICs = 0.02-50 μg/ml). Davercin is non-toxic to mice and rats (LD₅₀s = 4.05 and 5.9 g/kg, respectively). Formulations containing davercin have been used to treat a variety of urogenital bacterial infections.

Uses

Davercin (erythromycin A cyclic 11,12-carbonate) is a first generation semi-synthetic erythromycin. Davercin is prepared by coupling the 11- and 12-OH groups to form a cyclic carbonate. This simple modification improves the stability and hydrophobicity of the macrocyclic structure. Davercin shows comparable or better in vitro potency, low host toxicity and improved pharmacokinetics compared with erythromycin.

Uses

Erythromycin Cyclocarbonate is a derivative of Erythromycin (E649950), an antibcterial agent working on the 50S ribosomal subunit.

Definition

ChEBI: Davercin is an aminoglycoside.

Davercin(55224-05-0)Related Product Information

• Erythromycin
• 3-Dimethylaminopropylamine
• CYCLANDELATE
• CHLOROPHOSPHONAZO III
• Dimethyl carbonate
• Ethylene carbonate
• Lithium carbonate
• Calcium carbonate
• Sodium carbonate
• Roxithromycin
• CYCLOPENTOLATE
• Erythromycin Impurity 9
• DIBUTYL CARBONATE
• 4-ETHYL-1,3-DIOXOLAN-2-ONE
• (S)-(-)-Propylene Carbonate
• (R)-(+)-Propylene carbonate
• 4-HYDROXYMETHYL-1,3-DIOXOLAN-2-ONE
• (R)-(+)-4-(METHOXYMETHYL)-1,3-DIOXOLAN-2-ONE