Basic information Safety Supplier Related

BISINDOLYLMALEIMIDE I HYDROCHLORIDE

Basic information Safety Supplier Related

BISINDOLYLMALEIMIDE I HYDROCHLORIDE Basic information

Product Name:
BISINDOLYLMALEIMIDE I HYDROCHLORIDE
Synonyms:
  • BIM 1 hydrochloride
  • 3-[1-(dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride
  • BisindolylMaleiMide I( Hydrochloride Salt)
  • BisindolylMaleiMide I . hydrochloride [GF-109203K
  • 3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride
  • 3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
  • Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem
  • GF 109203X hydrochloride >=95%
CAS:
176504-36-2
MF:
C25H25ClN4O2
MW:
448.95
Mol File:
176504-36-2.mol
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BISINDOLYLMALEIMIDE I HYDROCHLORIDE Chemical Properties

storage temp. 
2-8°C
solubility 
DMF: 10 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL
form 
Orange-red solid
color 
Orange to red
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Safety Information

WGK Germany 
3
HS Code 
2933998090
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BISINDOLYLMALEIMIDE I HYDROCHLORIDE Usage And Synthesis

Description

Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine . It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα, β1, β2, γ, δ, and ε isozymes. BIM I directly inhibits glycogen synthase kinase 3 (GSK3) in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM). It also competitively antagonizes the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 61 nM.

Uses

GF 109203X hydrochloride has been used to inhibit protein kinase C in human neuroblastoma-derived kelly cells.

General Description

GF 109203X prevents collagen-triggered adenosine and three phosphate (ATP) secretion. It also inhibits collagen and α-thrombin-induced platelet aggregation. It functions as an inhibitor of glycogen synthase kinase-3 (GSK-3). GF 109203X also functions as an anti-inflammatory agent.

Biochem/physiol Actions

Inhibitor of protein kinase C; potent inhibitor of GSK-3.

BISINDOLYLMALEIMIDE I HYDROCHLORIDESupplier

Sigma-Aldrich
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Shanghai EFE Biological Technology Co., Ltd.
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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