5-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Chemical Properties

Melting point:

193.5-195.5℃

Boiling point:

374.2±22.0 °C(Predicted)

Density 

1.287±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

form 

solid

pka

8.29±0.10(Predicted)

color 

Pale yellow

Safety Information

Risk Statements 

20/21/22

Safety Statements 

24/25-36/37

HS Code 

29333990

5-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Usage And Synthesis

Chemical Properties

Yellow solid

Uses

Methyl 5-hydroxypyridine-2-carboxylate is a phenolic acid that can found in the stems of Mahonia fortune. Methyl 5-hydroxypyridine-2-carboxylate exhibits NO inhibitory effects in vitro[1].

Synthesis

1. add methanol (70 mL) to 5-hydroxypyridine-2-carboxylic acid (5.01 g, 36.0 mmol). 2. sulfuric acid (5.8 mL, 110 mmol) was added slowly and dropwise to the above mixture. 3. The reaction mixture was stirred overnight at 75 °C. 4. 4. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure. 5. 5. The residue was dissolved in ethyl acetate (EtOAc). 6. 6. Saturated aqueous sodium bicarbonate (NaHCO?) is added to the solution and the pH is adjusted to 3. 7. 7. The precipitate was collected by filtration and dried under vacuum. 8. 8. The remaining aqueous phase was extracted with ethyl acetate. 9. The organic phases were combined, washed with saturated brine and dried over anhydrous sodium sulfate (Na?SO?). 10. The organic phases were concentrated under pressure to give the solid product methyl 5-hydroxy-2-pyridinecarboxylate (5.3 g, 96% yield), which could be used for subsequent reactions without further purification. 11. LCMS analysis: calculated value C?H?NO?([M+H]?) m/z = 154.1; measured value: 154.1.

References

[1] Liu L, et, al. Simultaneous characterisation of multiple Mahonia fortunei bioactive compounds in rat plasma by UPLC-MS/MS for application in pharmacokinetic studies and anti-inflammatory activity in vitro. J Pharm Biomed Anal. 2020 Feb 5;179:113013. DOI:10.1016/j.jpba.2019.113013

5-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER(30766-12-2)Related Product Information

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