1,4-Bis(N,N'-diethylene phosphamide)piperazine
1,4-Bis(N,N'-diethylene phosphamide)piperazine Basic information
- Product Name:
- 1,4-Bis(N,N'-diethylene phosphamide)piperazine
- Synonyms:
-
- 1,4-Bis(N,N'-diethylene phosphamide)piperazine
- dipin
- 1,4-PIPERAZINEDIHYLBIS(BIS(1-AZIRIDINYL)-PHOPHINEOXIDE
- PHOSPHINEOXIDE,1,4-PIPERAZINEDIYLBIS(BIS(1-AZIRIDINYL)-
- 1,4-Piperazinediylbis[bis(1-aziridinyl)phosphine oxide]
- Dipine
- Piperazine, 1,4-bis[bis(1-aziridinyl)phosphinyl]-
- NSC 80096
- CAS:
- 738-99-8
- MF:
- C12H24N6O2P2
- MW:
- 346.31
- Mol File:
- 738-99-8.mol
1,4-Bis(N,N'-diethylene phosphamide)piperazine Chemical Properties
- Melting point:
- 187°
- form
- solid
- color
- Crystals from C6H6
1,4-Bis(N,N'-diethylene phosphamide)piperazine Usage And Synthesis
Uses
Antineoplastic agent-1 is an alkylating agent and a genotoxic agent that can induce DNA damage. Antineoplastic agent-1 can lead to irreversible damage and progressive death of liver cells due to necroptosis and apoptosis. Antineoplastic agent-1 can cause alkylation damage to hematopoietic cells and stromal cells in the bone marrow. Antineoplastic agent-1 can be used in tumor research[1][2].
Safety Profile
Poison by ingestion,intraperitoneal, and subcutaneous routes. Humanmutation data reported. When heated to decomposition itemits very toxic fumes of POx and NOx.
References
[1] Factor VM, Radaeva SA, Thorgeirsson SS. Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse. Am J Pathol. 1994 Aug;145(2):409-22. PMID:8053498
[2] Jensen MR, et al. Regulation of cyclin G1 during murine hepatic regeneration following Dipin-induced DNA damage. Hepatology. 1998 Aug;28(2):537-46. DOI:10.1002/hep.510280235