Tolindate
Tolindate Basic information
- Product Name:
- Tolindate
- Synonyms:
-
- Dalnate
- Methyl(3-methylphenyl)thiocarbamic acid O-(indan-5-yl) ester
- Carbamothioic acid, N-methyl-N-(3-methylphenyl)-, O-(2,3-dihydro-1H-inden-5-yl) ester
- CAS:
- 27877-51-6
- MF:
- C18H19NOS
- MW:
- 297.41
- Mol File:
- 27877-51-6.mol
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Tolindate Chemical Properties
- Melting point:
- 94-95°
- Boiling point:
- 425.1±55.0 °C(Predicted)
- Density
- 1.208±0.06 g/cm3(Predicted)
- pka
- -0.43±0.50(Predicted)
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Tolindate Usage And Synthesis
Uses
Tolindate is a potent PXR agonist with an EC50 value of 8.3 μM. Tolindate shows antifungal activity[1][2].
Definition
ChEBI: Tolindate is a member of indanes.
References
[1] Lynch C, et al. Characterization of human pregnane X receptor activators identified from a screening of the Tox21 compound library. Biochem Pharmacol. 2021 Feb;184:114368. DOI:10.1016/j.bcp.2020.114368
[2] Pastor L, et al. New antifungals selected by molecular topology. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2577-82. DOI:10.1016/s0960-894x(98)00460-0