5-INDANOL
5-INDANOL Basic information
- Product Name:
- 5-INDANOL
- Synonyms:
-
- 2,3-dihydro-1h-inden-5-o
- Indanol-5
- INDAN-5-OL
- 5-INDANOL
- 5-HYDROXYHYDRINDENE
- 5-HYDROXYINDAN
- 1H-Inden-5-ol, 2,3-dihydro-
- Indan-5-ol 98%
- CAS:
- 1470-94-6
- MF:
- C9H10O
- MW:
- 134.18
- EINECS:
- 216-006-3
- Product Categories:
-
- Indane/Indanone and Derivatives
- Mol File:
- 1470-94-6.mol
5-INDANOL Chemical Properties
- Melting point:
- 51-53 °C (lit.)
- Boiling point:
- 255 °C (lit.)
- Density
- 0.8540 (rough estimate)
- refractive index
- 1.5630 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- 6.3g/l
- pka
- 10.37±0.20(Predicted)
- form
- powder to crystal
- color
- slightly brown
- BRN
- 1936314
- CAS DataBase Reference
- 1470-94-6(CAS DataBase Reference)
- EPA Substance Registry System
- 5-Indanol (1470-94-6)
Safety Information
- Hazard Codes
- Xn,Xi
- Risk Statements
- 21-20/21/22
- Safety Statements
- 36/37-36
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- NK7525000
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29062900
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
5-INDANOL Usage And Synthesis
Uses
5-Indanol is a 5-hydroxyindole analog with weak inhibitory activity against human melanoma tyrosinase. 5-Indanol is also used as a reagent in the preparation of Sodium Indanylcarbinicillin; a compound which has been shown to reduce blood pressure in mammals and also has been used as a β-lactam antibiotic.
Description
5-Indanol, mp 54–55 ℃, bp 255 ℃, is produced from indan [496-11-7] by a sulfonation–alkali-fusion process. A synthesis for 1,1,3,3-tetraalkylindanols was developed by Bayer, which involves the reaction of isoolefins with secondary alkenylphenols (or compounds generating them under the reaction conditions) at 100–250 ℃ and in the presence of acidic catalysts. An example is the reaction of isobutene with bisphenol A in the presence of acid-activated clays which yields 1,1,3,3-tetramethyl-5-indanol [53718-26-6], mp 115 ℃, bp (2.66 kPa) 156 ℃, in a yield of 80% of the theoretical, and 4-tert-butylphenol as a coproduct.
Chemical Properties
light brown to grey-brown crystalline powder or
Uses
5-Indanol is a 5-hydroxyindole analog with weak inhibitory activity against human melanoma tyrosinase. 5-Indanol is also used as a reagent in the preparation of Sodium Indanylcarbinicillin (S635000); a compound which has been shown to reduce blood pressure in mammals and also has been used as a b-lactam antibiotic.
Definition
ChEBI: A member of the class of phenols that is indan which has been hydroxylated at position 5.
Purification Methods
Crystallise 5-hydroxyindane from pet ether (m 56o) or pentane (m 59-60o). It has UV with max at 283.5nm (cyclohexane). The 3,5-dinitrobenzoyl derivative has m 156o. [Beilstein 6 III 2428, 6 IV 3829.]
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5-INDANOL(1470-94-6)Related Product Information
- 4,6-bis(isopropyl)-1,1,3,3-tetramethylindan-5-ol
- 6-Hydroxy-1-indanone
- Hematoxylin
- 5,5',6,6'-TETRAHYDROXY-3,3,3',3'-TETRAMETHYL-1,1'-SPIROBISINDANE
- 4,5-DIMETHOXY-1-INDANONE
- 5-METHOXY-1-INDANONE-3-ACETIC ACID
- 5-METHOXYINDAN
- 6-Methoxy-1H-indanone
- R(+)-IAA-94
- HEMATOXYLIN
- 5-Methoxy-1-indanone
- 5-INDANOL
- 5,6-Dimethoxy-1-indanone
- BRAZILIN
- 3,3,3',3'-TETRAMETHYL-5,5',6,6'-TETRAPROPOXY-1,1'-SPIROBIINDANE
- (1S,2S)-1-Amino-2-indanol
- 2-INDANOL 99%,2-INDANOL
- 1-METHOXY-2-INDANOL,1-METHOXY-2-INDANOL 98+%