NORTRIPTYLINE-D3 HYDROCHLORIDE Chemical Properties

Flash point:

9℃

storage temp. 

-20°C

form 

liquid

Safety Information

Hazard Codes 

F,T

Risk Statements 

11-23/24/25-39/23/24/25

Safety Statements 

7-16-36/37-45

RIDADR 

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany 

2

NORTRIPTYLINE-D3 HYDROCHLORIDE Usage And Synthesis

Uses

• Mass spectrometry standard: Nortriptyline-D3 hydrochloride solution is utilized as a high-precision internal standard in mass spectrometry to quantify nortriptyline levels in biological samples, essential for clinical pharmacokinetic studies and therapeutic drug monitoring.
• Metabolite research: As a stable isotope-labeled nortriptyline, it aids in metabolite profiling, helping researchers identify and quantify nortriptyline metabolites in various matrices, which is crucial for understanding drug metabolism and disposition.
• Pharmacokinetic studies: The solution is applied in pharmacokinetic research to assess the absorption, distribution, metabolism, and excretion (ADME) of nortriptyline, providing insights into the drugμs efficacy and safety profiles.
• Quantitative analysis: In bioanalytical research, Nortriptyline-D3 hydrochloride serves as a standard in developing and validating analytical methods, ensuring accuracy and reproducibility in the quantification of nortriptyline in pharmaceutical formulations and clinical samples.

General Description

Nortriptyline is a second generation tricyclic antidepressant (TCA) marketed under trade names such as Sensoval, Aventyl^?, and Pamelor^? for treatment of major depression. Nortriptyline is also an active metabolite of the TCA amitriptyline. This certified Snap-N-Spike^? Solution is suitable as an internal standard for quantitation of nortriptyline levels by LC/MS or GC/MS in clinical toxicology, forensic analysis, urine drug testing, isotope dilution methods, or medication monitoring applications.

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