Iso Desloratadine Chemical Properties

Melting point:

>65°C (dec.)

Boiling point:

454.7±45.0 °C(Predicted)

Density 

1.212

storage temp. 

Amber Vial, Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

9.28±0.10(Predicted)

form 

Solid

color 

Off-White to Red

Stability:

Hygroscopic, Light Sensitive

Iso Desloratadine Usage And Synthesis

Uses

Degradation product of Desloratadine

Uses

Iso Desloratadine (Desloratadine EP Impurity B) is an impurity of Desloratadine (D290250), which is a nonsedating-type histamine H1-receptor antagonist. Desloratadine is an active metabolite of Loratadine (L469575). Also inhibits generation and release of inflammatory mediators from basophils and mast cells. An impurity arising in the synthesis of Rupatadine (R701650).

Iso Desloratadine(183198-49-4)Related Product Information

• Desloratadine Epoxide
• DESLORATADINE-D4
• Desloratadine D5
• Desloratadine IMpurity 3
• 8-Chloro-11-fluoro-6,11-dihydro-11-(4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
• 8-Dechloro-9-chloro Desloratadine
• Desloratadine IMpurity B
• Desloratadine N-Hydroxypiperidine
• Desloratadine IMpurity 1
• Desloratadine IMpurity 6
• Desloratadine
• 5,6-Dehydro-N-methyl Desloratadine
• IMp. A (EP): Ethyl 4-[(11RS)-8-Chloro-11-hydroxy-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]piperidine-1-carboxylate
• 8-Deschloro-8-bromo-N-methyl Desloratadine
• Desloratadine Pyridine N-oxide
• Desloratadine Citric Amide
• Desloratadine N-Carboxylic Acid Methyl Ester
• 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine-d 1-Oxide