KRP-203
KRP-203 Basic information
- Product Name:
- KRP-203
- Synonyms:
-
- 2-Amino-2-[2-[2-chloro-4-[[3-(phenylmethoxy)phenyl]thio]phenyl]ethyl]-1,3-propanediol Hydrochloride
- KRP-203
- 2-Amino-2-(2-(4-(3-benzyloxyphenylthio)-2-chlorophenyl)ethyl)-1,3-propanediol hydrochloride
- KRP-203 (hydrochloride)
- 2-Amino-2-(4-((3-(benzyloxy)phenyl)thio)-2-chloro-phenethyl)propane-1,3-diol hydrochloride
- KRP203/2-AMino-2-(2-(4-(3-benzyloxyphenylthio)-2-chlorophenyl)ethyl)-1,3-propanediol hydrochloride
- 2-Amino-2-[2-[2-chloro-4-[[3-(phenylmethoxy)phenyl]thio]phenyl]ethyl]-1,3-propanediol
- 2-AMINO-2-[2-[2-CHLORO-4-[[3-(PHENYLMETHOXY)PHENYL]THIO]PHENYL]ETHYL]-1,3-PROPANEDIOL HCL
- CAS:
- 509088-69-1
- MF:
- C24H27Cl2NO3S
- MW:
- 480.45
- EINECS:
- 1312995-182-4
- Product Categories:
-
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Amines
- Aromatics
- Sulfur & Selenium Compounds
- Mol File:
- 509088-69-1.mol
More
Less
KRP-203 Chemical Properties
- Melting point:
- 199-200 ºC (DEC.)
- storage temp.
- Refrigerator
- solubility
- DMSO, Methanol
- form
- Solid
- color
- White to Off-White
More
Less
KRP-203 Usage And Synthesis
Uses
A novel immunomodulator
Uses
A novel sphingosine-1-phosphate receptor agonists in the treatment of autoimmune diseases. Immunosuppressant.
in vivo
Mocravimod hydrochloride (KRP-203) ameliorates atherosclerosis in LDL-R / Mice[1].
Mocravimod hydrochloride (KRP-203) (orally; 0.1 and 1 mg/kg/day; for 100 days) prolongs graft survival and attenuates chronic rejection in mHC-disparate rat heart allografts[2].
| Animal Model: | Inbred male DA (MHC haplotype: RT1a) rats[2] |
| Dosage: | 0.1 and 1 mg/kg |
| Administration: | Orally; daily; for 100 days |
| Result: | Prolonged graft survival and attenuated chronic rejection in mHC-disparate rat heart allografts. |
KRP-203Supplier
J & K SCIENTIFIC LTD.
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070
- info@chemlin.com.cn
Chemsky(shanghai)International Co.,Ltd.
- Tel
- 021-50135380
- shchemsky@sina.com
Hubei XinyuanShun Chemical Co., Ltd.
- Tel
- 13971561712, 13995564702, 027-50664929
- hbeixys2001@163.com
ShangHai KenEn Chemical Technology Co., Ltd.
- Tel
- 13120367189
- mychess007@163.com