Almokalant
Almokalant Basic information
- Product Name:
- Almokalant
- Synonyms:
-
- Almokalant
- H 234?/09
- Benzonitrile, 4-[3-[ethyl[3-(propylsulfinyl)propyl]amino]-2-hydroxypropoxy]-
- CAS:
- 123955-10-2
- MF:
- C18H28N2O3S
- MW:
- 352.496
- Mol File:
- 123955-10-2.mol
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Almokalant Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
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Almokalant Usage And Synthesis
Uses
Almokalant is a class III antiarrhythmic agent, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current.
in vivo
Almokalant (125 μmol/kg, p.o.) induces cardiovascular defects, orofacial clefts, and tail defects in pregnant rats, after administration on Day 11. Almokalant also causes in pregnant rats[1].
References
[1] Wellfelt K, et al. Teratogenicity of the class III antiarrhythmic drug almokalant. Role of hypoxia and reactive oxygen species. Reprod Toxicol. 1999 Mar-Apr;13(2):93-101. DOI:10.1016/s0890-6238(98)00066-5
AlmokalantSupplier
Shenzhen Botel Biotechnology Co. Ltd.
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Fan De(Beijing) Biotechnology Co., Ltd.
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TargetMol Chemicals Inc.
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Hubei Ipure Biology Co., Ltd
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Jinan ponder chemical co. LTD
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