HEXAMETHONIUM CHLORIDE
HEXAMETHONIUM CHLORIDE Basic information
- Product Name:
- HEXAMETHONIUM CHLORIDE
- Synonyms:
-
- 6-hexanediaminium,n,n,n,n’,n’,n’-hexamethyl-dichloride
- hexonchloride
- hexonechloride
- hiohexchloride
- methiumchloride
- A,W-BIS(TRIMETHYLAMMONIUM)HEXANE DICHLORIDE
- HEXAMETHYLENEBIS[TRIMETHYLAMMONIUM CHLORIDE]
- HEXAMETHONIUM CHLORIDE
- CAS:
- 60-25-3
- MF:
- C12H30Cl2N2
- MW:
- 273.29
- EINECS:
- 200-465-1
- Product Categories:
-
- Ammonium Chlorides (Quaternary)
- Quaternary Ammonium Compounds
- Mol File:
- 60-25-3.mol
HEXAMETHONIUM CHLORIDE Chemical Properties
- Melting point:
- 292°C(dec.)(lit.)
- Boiling point:
- 423.36°C (rough estimate)
- Density
- 1.0558 (rough estimate)
- refractive index
- 1.6400 (estimate)
- solubility
- H2O: soluble
- form
- solid (hygroscopic)
- color
- white
- Water Solubility
- almost transparency
- BRN
- 3714806
- CAS DataBase Reference
- 60-25-3
- EPA Substance Registry System
- 1,6-Hexanediaminium, N,N,N,N',N',N'-hexamethyl-, dichloride (60-25-3)
MSDS
- Language:English Provider:SigmaAldrich
HEXAMETHONIUM CHLORIDE Usage And Synthesis
Chemical Properties
White, crystalline, hygroscopic powder; faint odor. Very soluble in water; soluble in alcohol, methanol, and n-propanol; insoluble in chloroform and ether. Available commercially as unhydrated form or as dihydrate.
Uses
Hexamethonium Chloride is a ganglionic nicotinic receptor blocker.
Uses
Hexamethonium chloride has been used to block the responses of nicotinic receptors towards it agonists. It has also been used to study the mechanosensitivity of viscerofugal neurons.
Uses
Medicine (antihypertensive).
General Description
Nicotinic acetylcholine receptor (nAChR) forms a ligand-gated ion channel made up of four different subunits. Each subunit contains an extracellular amino-terminal domain (hydrophilic) and carboxylic terminal domain and four transmembrane domains. nAChR is an allosteric and transmembrane protein localized to the neuromuscular junction.
Biochem/physiol Actions
Hexamethonium chloride preferentially blocks nicotinic receptors at autonomic ganglia, crosses blood-brain barrier only at high doses. Nicotinic acetylcholine receptor (nAChR) is responsible for cognitive functions. Blocking this receptor results in cognitive impairment. nAChR antagonist is used to study the effect of loss of receptor function. Hexamethonium has a peripheral action over blocking the nAChR.
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