Basic information Safety Supplier Related

HEXAMETHONIUM CHLORIDE

Basic information Safety Supplier Related

HEXAMETHONIUM CHLORIDE Basic information

Product Name:
HEXAMETHONIUM CHLORIDE
Synonyms:
  • 6-hexanediaminium,n,n,n,n’,n’,n’-hexamethyl-dichloride
  • hexonchloride
  • hexonechloride
  • hiohexchloride
  • methiumchloride
  • A,W-BIS(TRIMETHYLAMMONIUM)HEXANE DICHLORIDE
  • HEXAMETHYLENEBIS[TRIMETHYLAMMONIUM CHLORIDE]
  • HEXAMETHONIUM CHLORIDE
CAS:
60-25-3
MF:
C12H30Cl2N2
MW:
273.29
EINECS:
200-465-1
Product Categories:
  • Ammonium Chlorides (Quaternary)
  • Quaternary Ammonium Compounds
Mol File:
60-25-3.mol
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HEXAMETHONIUM CHLORIDE Chemical Properties

Melting point:
292°C(dec.)(lit.)
Boiling point:
423.36°C (rough estimate)
Density 
1.0558 (rough estimate)
refractive index 
1.6400 (estimate)
solubility 
H2O: soluble
form 
solid (hygroscopic)
color 
white
Water Solubility 
almost transparency
BRN 
3714806
CAS DataBase Reference
60-25-3
EPA Substance Registry System
1,6-Hexanediaminium, N,N,N,N',N',N'-hexamethyl-, dichloride (60-25-3)
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Safety Information

WGK Germany 
3
RTECS 
BQ8650000
HS Code 
2923.90.0100

MSDS

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HEXAMETHONIUM CHLORIDE Usage And Synthesis

Chemical Properties

White, crystalline, hygroscopic powder; faint odor. Very soluble in water; soluble in alcohol, methanol, and n-propanol; insoluble in chloroform and ether. Available commercially as unhydrated form or as dihydrate.

Uses

Hexamethonium Chloride is a ganglionic nicotinic receptor blocker.

Uses

Hexamethonium chloride has been used to block the responses of nicotinic receptors towards it agonists. It has also been used to study the mechanosensitivity of viscerofugal neurons.

Uses

Medicine (antihypertensive).

General Description

Nicotinic acetylcholine receptor (nAChR) forms a ligand-gated ion channel made up of four different subunits. Each subunit contains an extracellular amino-terminal domain (hydrophilic) and carboxylic terminal domain and four transmembrane domains. nAChR is an allosteric and transmembrane protein localized to the neuromuscular junction.

Biochem/physiol Actions

Hexamethonium chloride preferentially blocks nicotinic receptors at autonomic ganglia, crosses blood-brain barrier only at high doses. Nicotinic acetylcholine receptor (nAChR) is responsible for cognitive functions. Blocking this receptor results in cognitive impairment. nAChR antagonist is used to study the effect of loss of receptor function. Hexamethonium has a peripheral action over blocking the nAChR.

HEXAMETHONIUM CHLORIDESupplier

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