PROGLUMIDE, SODIUM SALT
PROGLUMIDE, SODIUM SALT Basic information
- Product Name:
- PROGLUMIDE, SODIUM SALT
- Synonyms:
-
- DL-4-(BENZOYLAMINO)-5-(DIPROPYLAMINO)-5-OXOPENTANOIC ACID, NA
- 4-BENZOYLAMINO-5-DIPROPYLAMINO-5-OXOPENTANOIC ACID SODIUM
- PROGLUMIDE SODIUM
- PROGLUMIDE, SODIUM SALT
- 4-benzamido-n,n-dipropyl-,sodiumsalt,dl-glutaramicaci
- SODIUM;4-BENZAMIDO-5-(DIPROPYLAMINO)-5-OXOPENTANOATE
- 4-benzamido-5-(dipropylamino)-5-oxopentanoate
- 4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid sodium salt
- CAS:
- 99247-33-3
- MF:
- C18H27N2NaO4
- MW:
- 358.41
- Mol File:
- 99247-33-3.mol
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PROGLUMIDE, SODIUM SALT Chemical Properties
- storage temp.
- Desiccate at RT
- solubility
- H2O: soluble
- form
- solid
- color
- white
- Water Solubility
- Soluble to 100 mM in water
MSDS
- Language:English Provider:SigmaAldrich
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PROGLUMIDE, SODIUM SALT Usage And Synthesis
Uses
Proglumide sodium salt has been used to study the effects of proglumide on macronutrient selection in European sea bass Dicentrarchus labrax, L.
Biochem/physiol Actions
Proglumide sodium salt is a non-peptide cholecystokinin receptor antagonist that has greater selectivity for the CCKA subtype. It selectively blocks central nervous system effects. Proglumide sodium salt is orally active.
in vivo
Proglumide (250-750 mg/kg; intraperitoneal injection; adult male Sprague Dawley rats) treatment is significantly effective in ameliorating the seizure activities, cognitive dysfunctions, and cerebral oxidative stress[1].
| Animal Model: | Adult male Sprague Dawley rats (200-250?g; 2 months old) are induced status epilepticus (SE)[1] |
| Dosage: | 250 mg/kg, 500 mg/kg, and 750?mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Dose-dependently and significantly increased the latencies to seizure and SE. Significantly and dose-dependently attenuated Li-PC (SE) induced increase in thiobarbituric acid (TBARS) and catalase (CAT), attenuated Li-Pc induced decrease in SOD, and attenuated depletion of GSH and glutathione-S transferase (GST) in the hippocampus and striatum. |
storage
Desiccate at RT
PROGLUMIDE, SODIUM SALTSupplier
Guangzhou Isun Pharmaceutical Co., Ltd
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- 020-39119399 18927568969
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ShangHai Caerulum Pharma Discovery Co., Ltd.
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- 18149758185
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Sigma-Aldrich
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Shanghai YuanYe Biotechnology Co., Ltd.
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TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
- marketing@targetmol.com