1-formylisoquinoline thiosemicarbazone Chemical Properties

Density 

1.2608 (rough estimate)

refractive index 

1.5500 (estimate)

Safety Information

Toxicity

LD50 intraperitoneal in mouse: 800mg/kg

1-formylisoquinoline thiosemicarbazone Usage And Synthesis

Uses

IQ 1 disrupts Wnt signaling. IQ-1 in conjunction with Wnt3a has been shown to be sufficient to maintain murine embryonic stem cell proliferation in the absence of serum. Binds to the PR72/PR130 subunit of protein phosphatase PP2A preventing β-catenin from switching co-activator usage from CBP to p300 leading to an increase in β-catenin/CBP-driven transcription at the expense of β-catenin/p300-driven transcription.

1-formylisoquinoline thiosemicarbazone(2365-26-6)Related Product Information

• 1-formylisoquinoline thiosemicarbazone
• 2-Formylpyridine thiosemicarbazone