DU 717
DU 717 Basic information
- Product Name:
- DU 717
- Synonyms:
-
- DU 717
- 7-chloro-3-(4-methyl-1-piperazinyl)-2H-1,2,4-benzothiadiazine 1,1-dioxide
- 2H-1,2,4-Benzothiadiazine, 7-chloro-3-(4-methyl-1-piperazinyl)-, 1,1-dioxide
- DU717, 10 mM in DMSO
- 7-Chloro-3-(4-methyl-1-piperazinyl)-4H-1,2,4-benzothiadiazine-1,1-dioxide
- CAS:
- 59943-31-6
- MF:
- C12H15ClN4O2S
- MW:
- 314.796
- Mol File:
- 59943-31-6.mol
DU 717 Chemical Properties
- Density
- 1.3907 (rough estimate)
- refractive index
- 1.5630 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
DU 717 Usage And Synthesis
Uses
DU-717 is an antihypertensive agent.
in vivo
A gas chromatographic method has been developed which enables accurate determination of a new antihypertensive agent, DU-717, in plasma. Accurate determinations are possible over a concentration range from 10 to 150 ng/mL of DU-717 in plasma at a relative standard deviation of 6.2%. The minimum detectable concentration is 1 ng/mL. Plasma levels of DU-717 in spontaneously hypertensive and normotensive rats following single oral administrations (10 mg/kg) have also been determined[1].
References
[1] Yamaguchi T, et al. Determination of 7-chloro-3-(4-methyl-1-piperazinyl)-4h-1,2,4-benzothiadiazine-1,1-dioxide (DU-717) in plasma using electron-capture gas chromatography. J Chromatogr. 1978 Oct 11;160(1):181-90. DOI:10.1016/s0021-9673(00)91794-1
[2] R Horie. rats (ALR) and normotensive atherogenic rats (NAR).
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