5-BROMO-IMIDAZO[1,2-A]PYRIDINE Chemical Properties

Melting point:

61-64℃

Density 

1.69±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), DMSO (Slightly)

form 

Solid

pka

5.15±0.50(Predicted)

color 

Pale Brown to Light Brown

InChI

InChI=1S/C7H5BrN2/c8-6-2-1-3-7-9-4-5-10(6)7/h1-5H

InChIKey

CCOFGVWHMYYDBG-UHFFFAOYSA-N

SMILES

C12=NC=CN1C(Br)=CC=C2

Safety Information

WGK Germany 

3

HS Code 

2933599590

5-BROMO-IMIDAZO[1,2-A]PYRIDINE Usage And Synthesis

Uses

5-Bromoimidazo[1,2-a]pyridine can be used as HPK1 antagonists to treat HPK1-mediated disorders.

Synthesis

General procedure for the synthesis of 5-bromoimidazo[1,2-a]pyridines from 5-bromoimidazo[1,2-a]pyridine hydrobromide: 1. Preparation of reactants: 2-bromo-1,1-diethoxyethane (3.64 g, 18.48 mmol) was added to a solution of 6-bromopyridin-2-ylamine (1.0 g, 5.77 mmol) in n-butanol (40 mL). 2. Reaction conditions: the mixture was refluxed overnight and then cooled to room temperature. 3. post-processing: the reaction mixture was filtered to give 1.3 g (81% yield) of 5-bromoimidazo[1,2-a]pyridine hydrobromide as a white solid. esms (M + +1): 198.9 m/z. 4. Neutralization step: Saturated sodium bicarbonate solution (300 mL) was added to an ethyl acetate suspension of 5-bromoimidazo[1,2-a]pyridine hydrobromide (13.0 g, 46.96 mmol). 5. Isolation and purification: the organic layer was separated, washed with saturated sodium bicarbonate solution, dried with magnesium sulfate and concentrated under reduced pressure to give 9.7 g (100% yield) of 5-bromoimidazo[1,2-a]pyridine as a white solid.

References

[1] Patent: WO2003/76398, 2003, A2. Location in patent: Page/Page column 20
[2] Patent: WO2003/76442, 2003, A1. Location in patent: Page/Page column 40

5-BROMO-IMIDAZO[1,2-A]PYRIDINE(69214-09-1)Related Product Information

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