5-BROMO-IMIDAZO[1,2-A]PYRIDINE
- Product Name
- 5-BROMO-IMIDAZO[1,2-A]PYRIDINE
- CAS No.
- 69214-09-1
- Chemical Name
- 5-BROMO-IMIDAZO[1,2-A]PYRIDINE
- Synonyms
- 5-BROMO-IMIDAZO[1,2-A]PYRIDINE;5-bromoH-imidazo[1,2-a]pyridine;Imidazo[1,2-a]pyridine, 5-bromo-;5-BROMOIMIDAZO[1,2-A]PYRIDINE, 95+%;5-Bromoimidazo[1,2-a]pyridine;5-BROMO-5H-IMIDAZO[2,1-B][1,3]OXAZINE;5-Bromo-1,5-dihydroimidazo[1,2-a]pyridine
- CBNumber
- CB3133691
- Molecular Formula
- C7H5BrN2
- Formula Weight
- 197.03
- MOL File
- 69214-09-1.mol
5-BROMO-IMIDAZO[1,2-A]PYRIDINE Property
- Melting point:
- 61-64℃
- Density
- 1.69±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- form
- Solid
- pka
- 5.15±0.50(Predicted)
- color
- Pale Brown to Light Brown
- InChI
- InChI=1S/C7H5BrN2/c8-6-2-1-3-7-9-4-5-10(6)7/h1-5H
- InChIKey
- CCOFGVWHMYYDBG-UHFFFAOYSA-N
- SMILES
- C12=NC=CN1C(Br)=CC=C2
Safety
- WGK Germany
- 3
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 750964
- Product name
- 5-Bromoimidazo[1,2-a]pyridine
- Purity
- 96%
- Packaging
- 500mg
- Price
- $86.3
- Updated
- 2023/06/20
- Product number
- B696308
- Product name
- 5-Bromoimidazo[1,2-a]pyridine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- B696308
- Product name
- 5-Bromoimidazo[1,2-a]pyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR30602
- Product name
- 5-Bromoimidazo[1,2-a]pyridine
- Packaging
- 1g
- Price
- $32
- Updated
- 2021/12/16
- Product number
- X0278
- Product name
- 5-Bromoimidazo[1,2-a]pyridine
- Packaging
- 1g
- Price
- $34
- Updated
- 2021/12/16
5-BROMO-IMIDAZO[1,2-A]PYRIDINE Chemical Properties,Usage,Production
Uses
5-Bromoimidazo[1,2-a]pyridine can be used as HPK1 antagonists to treat HPK1-mediated disorders.
Synthesis
603301-13-9
69214-09-1
General procedure for the synthesis of 5-bromoimidazo[1,2-a]pyridines from 5-bromoimidazo[1,2-a]pyridine hydrobromide: 1. Preparation of reactants: 2-bromo-1,1-diethoxyethane (3.64 g, 18.48 mmol) was added to a solution of 6-bromopyridin-2-ylamine (1.0 g, 5.77 mmol) in n-butanol (40 mL). 2. Reaction conditions: the mixture was refluxed overnight and then cooled to room temperature. 3. post-processing: the reaction mixture was filtered to give 1.3 g (81% yield) of 5-bromoimidazo[1,2-a]pyridine hydrobromide as a white solid. esms (M + +1): 198.9 m/z. 4. Neutralization step: Saturated sodium bicarbonate solution (300 mL) was added to an ethyl acetate suspension of 5-bromoimidazo[1,2-a]pyridine hydrobromide (13.0 g, 46.96 mmol). 5. Isolation and purification: the organic layer was separated, washed with saturated sodium bicarbonate solution, dried with magnesium sulfate and concentrated under reduced pressure to give 9.7 g (100% yield) of 5-bromoimidazo[1,2-a]pyridine as a white solid.
References
[1] Patent: WO2003/76398, 2003, A2. Location in patent: Page/Page column 20
[2] Patent: WO2003/76442, 2003, A1. Location in patent: Page/Page column 40
5-BROMO-IMIDAZO[1,2-A]PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BROMO-IMIDAZO[1,2-A]PYRIDINE manufacturers
- Product
- 5-BROMO-IMIDAZO[1,2-A]PYRIDINE 69214-09-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-19
- Product
- 5-BROMO-IMIDAZO[1,2-A]PYRIDINE 69214-09-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-BROMO-IMIDAZO[1,2-A]PYRIDINE 69214-09-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09