ChemicalBook > CAS DataBase List > 5-BROMO-IMIDAZO[1,2-A]PYRIDINE

5-BROMO-IMIDAZO[1,2-A]PYRIDINE

Product Name
5-BROMO-IMIDAZO[1,2-A]PYRIDINE
CAS No.
69214-09-1
Chemical Name
5-BROMO-IMIDAZO[1,2-A]PYRIDINE
Synonyms
5-BROMO-IMIDAZO[1,2-A]PYRIDINE;5-bromoH-imidazo[1,2-a]pyridine;Imidazo[1,2-a]pyridine, 5-bromo-;5-BROMOIMIDAZO[1,2-A]PYRIDINE, 95+%;5-Bromoimidazo[1,2-a]pyridine;5-BROMO-5H-IMIDAZO[2,1-B][1,3]OXAZINE;5-Bromo-1,5-dihydroimidazo[1,2-a]pyridine
CBNumber
CB3133691
Molecular Formula
C7H5BrN2
Formula Weight
197.03
MOL File
69214-09-1.mol
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5-BROMO-IMIDAZO[1,2-A]PYRIDINE Property

Melting point:
61-64℃
Density 
1.69±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly)
form 
Solid
pka
5.15±0.50(Predicted)
color 
Pale Brown to Light Brown
InChI
InChI=1S/C7H5BrN2/c8-6-2-1-3-7-9-4-5-10(6)7/h1-5H
InChIKey
CCOFGVWHMYYDBG-UHFFFAOYSA-N
SMILES
C12=NC=CN1C(Br)=CC=C2
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Safety

WGK Germany 
3
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
750964
Product name
5-Bromoimidazo[1,2-a]pyridine
Purity
96%
Packaging
500mg
Price
$86.3
Updated
2023/06/20
TRC
Product number
B696308
Product name
5-Bromoimidazo[1,2-a]pyridine
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
B696308
Product name
5-Bromoimidazo[1,2-a]pyridine
Packaging
1g
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
OR30602
Product name
5-Bromoimidazo[1,2-a]pyridine
Packaging
1g
Price
$32
Updated
2021/12/16
AK Scientific
Product number
X0278
Product name
5-Bromoimidazo[1,2-a]pyridine
Packaging
1g
Price
$34
Updated
2021/12/16
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5-BROMO-IMIDAZO[1,2-A]PYRIDINE Chemical Properties,Usage,Production

Uses

5-Bromoimidazo[1,2-a]pyridine can be used as HPK1 antagonists to treat HPK1-mediated disorders.

Synthesis

603301-13-9

69214-09-1

General procedure for the synthesis of 5-bromoimidazo[1,2-a]pyridines from 5-bromoimidazo[1,2-a]pyridine hydrobromide: 1. Preparation of reactants: 2-bromo-1,1-diethoxyethane (3.64 g, 18.48 mmol) was added to a solution of 6-bromopyridin-2-ylamine (1.0 g, 5.77 mmol) in n-butanol (40 mL). 2. Reaction conditions: the mixture was refluxed overnight and then cooled to room temperature. 3. post-processing: the reaction mixture was filtered to give 1.3 g (81% yield) of 5-bromoimidazo[1,2-a]pyridine hydrobromide as a white solid. esms (M + +1): 198.9 m/z. 4. Neutralization step: Saturated sodium bicarbonate solution (300 mL) was added to an ethyl acetate suspension of 5-bromoimidazo[1,2-a]pyridine hydrobromide (13.0 g, 46.96 mmol). 5. Isolation and purification: the organic layer was separated, washed with saturated sodium bicarbonate solution, dried with magnesium sulfate and concentrated under reduced pressure to give 9.7 g (100% yield) of 5-bromoimidazo[1,2-a]pyridine as a white solid.

References

[1] Patent: WO2003/76398, 2003, A2. Location in patent: Page/Page column 20
[2] Patent: WO2003/76442, 2003, A1. Location in patent: Page/Page column 40

5-BROMO-IMIDAZO[1,2-A]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-IMIDAZO[1,2-A]PYRIDINE Suppliers

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View Lastest Price from 5-BROMO-IMIDAZO[1,2-A]PYRIDINE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
5-BROMO-IMIDAZO[1,2-A]PYRIDINE 69214-09-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-19
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-BROMO-IMIDAZO[1,2-A]PYRIDINE 69214-09-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-BROMO-IMIDAZO[1,2-A]PYRIDINE 69214-09-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

69214-09-1, 5-BROMO-IMIDAZO[1,2-A]PYRIDINERelated Search:

Methyl imidazo[1,2-a]pyridine-5-carboxylate 3,6-Dibromoimidazo[1,2-a]pyridine 5-METHYL-IMIDAZO[1,2-A]PYRIDINE 6-Bromoimidazo[1,2-a]pyridine Imidazo[1,2-a]pyridine, 6-fluoro- (9CI) 5-BROMO-IMIDAZO[1,2-A]PYRIDINE Imidazo[1,2-a]pyridine 5-Bromo-2-(4-iodo-phenyl)-imidazo[1,2-a]pyridine 5-BROMOIMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID 5-Bromo-2-tert-butyl-imidazo[1,2-a]pyridine 5-BROMO-IMIDAZO[1,2-A]PYRIDINE HBR 5-BROMO-2-CHLOROMETHYL-IMIDAZO[1,2-A]PYRIDINE 5-BROMO-3-IODO-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER ETHYL (5-BROMOIMIDAZO[1,2-A]PYRIDIN-2-YL)ACETATE 5-BROMO-2-METHYLIMIDAZO[1,2-A]PYRIDINE 5-Bromo-2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridine 5-Bromo-2-(4-nitro-phenyl)-imidazo[1,2-a]pyridine 4-(5-Bromo-imidazo[1,2-a]pyridin-2-yl)-benzoic acid methyl ester

  • 5-BROMO-IMIDAZO[1,2-A]PYRIDINE
  • 5-BROMOIMIDAZO[1,2-A]PYRIDINE, 95+%
  • 5-bromoH-imidazo[1,2-a]pyridine
  • 5-BROMO-5H-IMIDAZO[2,1-B][1,3]OXAZINE
  • 5-Bromo-1,5-dihydroimidazo[1,2-a]pyridine
  • Imidazo[1,2-a]pyridine, 5-bromo-
  • 5-Bromoimidazo[1,2-<i>a</i>]pyridine
  • 69214-09-1
  • API intermediates
  • Heterocycle-Pyridine series
  • Building Blocks
  • Imidazo[x,x-y]pyridine