glaucocalyxin A Chemical Properties

Melting point:

219.5-220.5℃ (ethyl ether )

Boiling point:

513.4±50.0 °C(Predicted)

Density 

1.22±0.1 g/cm3 (20 ºC 760 Torr)

storage temp. 

Store at -20°C

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

powder

pka

13.15±0.70(Predicted)

color 

White

InChI

InChI=1/C20H28O4/c1-10-11-5-6-12-19(4)8-7-14(21)18(2,3)13(19)9-15(22)20(12,16(10)23)17(11)24/h11-13,15,17,22,24H,1,5-9H2,2-4H3/t11-,12-,13+,15+,17+,19-,20-/s3

InChIKey

UCDVIBNDYLUWFP-WOOMQCEBNA-N

SMILES

[C@@]123C(=O)C(=C)[C@H](CC[C@@]1([H])[C@]1(C)CCC(=O)C(C)(C)[C@@]1([H])C[C@H]2O)[C@H]3O |&1:0,5,8,10,19,22,24,r|

glaucocalyxin A Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from the whole plant of Labiatae, Rabdosia japonica, Rubescens.

Uses

Glaucocalyxin A has the effect of anti-platelet aggregation and inhibits cancer cells.

Biological Activity

Glaucocalyxin A is an enantiomeric lauryl diterpene from Rabdosia japonica var. It inhibits the nuclear translocation of GLI1 by regulating the PI3K/Akt signaling pathway, thereby inducing apoptosis in osteosarcoma. Glaucocalyxin A has antitumor effect.

IC 50

PI3K

glaucocalyxin A(79498-31-0)Related Product Information

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