5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE Chemical Properties

Melting point:

269-270℃ (ethanol )

storage temp. 

2-8°C(protect from light)

form 

solid

Appearance

Yellow to brown Solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-20/21/22

Safety Statements 

3/7-36/37

HS Code 

29335990

5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE Usage And Synthesis

Chemical Properties

Off-white to light yellow solid

Synthesis

GENERAL METHODS: A mixture of 2-amino-4,5-dimethylthiophene-3-carboxamide (1 mmol) and compound (CAS:77287-34-4) (1 mmol) with formamide (5-6 mmol) in acetic acid (1 mmol) was placed in a microwave reactor and irradiated for 10 min at 130 °C under 300 W power. After completion of the reaction, the reaction mixture was cooled to room temperature and subsequently poured into cold water. The precipitate was collected by filtration, washed with water and finally recrystallized from ethanol to obtain the pure product. The product 5,6-dimethyl-3H-thieno[2,3-d]pyrimidin-4-one (4a) had a melting point of 180-183 °C; IR (cm^-1 ): 3320 (NH), 1670 (C=O); 1H-NMR (DMSO-d6) δ: 1.7 (s, 3H, CH3), 2.0 (s, 3H, CH3), 7.80 (s, 1H Pyrimidine-H), 10.00 (br.s, 1H, NH); MS: m/z 180 [M+] (95) (C8H8N2OS); Elemental analysis of calculated values (%): C: 53.33, H: 4.44, N: 15.55; measured values (%): C: 53.45, H: 4.30, N: 15.56.

References

[1] Oriental Journal of Chemistry, 2014, vol. 30, # 2, p. 469 - 477

5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE(18593-44-7)Related Product Information

• 3-(4-OXO-3,4,5,6,7,8-HEXAHYDRO-BENZO[4,5]THIENO[2,3-D]PYRIMIDIN-2-YL)-PROPIONIC ACID
• (1)Benzothieno(2,3-d)pyrimidin-4(3H)-one, 5,6,7,8-tetrahydro-3-amino-2 -(phenylamino)-
• (1)benzothieno(2,3-d)pyrimidin-4(1h)-one,2,3,5,6,7,8-hexahydro-3-methyl-2-thio
• ETHYL 5-METHYL-4-OXO-3,4-DIHYDROTHIENO[2,3-D]-PYRIMIDINE-6-CARBOXYLATE
• 2-MERCAPTO-3-PHENYL-5,6,7,8-TETRAHYDRO-3H-BENZO[4,5]THIENO[2,3-D]PYRIMIDIN-4-ONE
• AKOS 92543
• AKOS 94123
• 3-AMINO-5-ETHYL-2,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE
• 3-AMINO-2,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE
• 5,6-Dimethylthieno[2,3-d]pyrimidin-4(3H)-one ,97%
• 2-(MERCAPTOMETHYL)-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE
• 3-CYCLOHEXYL-2-MERCAPTO-5,6,7,8-TETRAHYDRO-3H-BENZO[4,5]THIENO[2,3-D]PYRIMIDIN-4-ONE
• AKOS BBS-00007197
• 7-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-2-[(2,4-DICHLOROBENZYL)SULFANYL]-3-METHYL-5,6,7,8-TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE
• AKOS BBS-00007188
• AKOS BBS-00007193
• 7-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-3-METHYL-2-SULFANYL-5,6,7,8-TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE
• 2-MERCAPTO-5,6,7,8-TETRAHYDRO-3H-BENZO[4,5]THIENO[2,3-D]PYRIMIDIN-4-ONE