2-PYRIMIDINEMETHANAMINE Chemical Properties

storage temp. 

2-8°C(protect from light)

solubility 

Chloroform (Sparingly), Methanol (Slightly)

form 

Oil

color 

Pale Yellow to Dark Yellow

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

2-PYRIMIDINEMETHANAMINE Usage And Synthesis

Chemical Properties

white powder

Uses

2-Pyrimidinemethanamine can be prepared to combat abiotic plant stress.

Synthesis

General procedure for the synthesis of 2-methylaminopyrimidine from 2-cyanopyrimidine: To a stirred solution of 2-cyanopyrimidine (10) (0.2 g, 0.9 mmol) in ethanol (1 mL) was added 10% palladium/carbon (20 mg) under a nitrogen atmosphere. The reaction mixture was stirred under hydrogen atmosphere (using a balloon to maintain atmospheric pressure) for 12 h. Upon completion of the reaction, it was filtered through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by neutral alumina column chromatography (eluent: ethyl acetate/hexane = 1:1) to afford 2-methylaminopyrimidine (24) (0.19 g, 95% yield). Thin layer chromatography (TLC) conditions: 50% ethyl acetate/hexane (Rf: 0.1). 1H NMR (400 MHz, CDCl3): δ 8.70 (d, J=5.2 Hz, 2H), 7.16 (t, J=4.8 Hz, 1H), 4.19 (s, 1H), 4.11-4.08 (m, 1H).

References

[1] Patent: WO2013/13238, 2013, A2. Location in patent: Page/Page column 42
[2] Patent: WO2014/120783, 2014, A1. Location in patent: Paragraph 00143
[3] Patent: US5312823, 1994, A

2-PYRIMIDINEMETHANAMINE(75985-45-4)Related Product Information

• 4-Pyrimidinemethanamine, N-methyl- (9CI),N-Methyl-4-pyrimidinemethanamine
• PEPLOMYCIN
• Talisomycin
• 4-AMINO-2-METHYL-5-PYRIMIDINEMETHANAMINE
• 4-CHLORO-N,6-DIMETHYLPYRIMIDIN-2-AMINE
• 4-Amino-5-aminomethyl-2-methylpyrimidine
• 4-Pyrimidinemethanamine (9CI)
• 5-Pyrimidinemethanamine (9CI),5-PYRIMIDINEMETHANAMINE
• Bleomycin
• BLEOMYCIN A2
• 2-Pyrimidinecarboxamide (6CI,7CI,9CI)
• 1-(4-CHLOROPYRIMIDIN-2-YL)METHANAMINE
• 5-(2,4-DICHLOROBENZYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-4,6-PYRIMIDINEDIAMINE
• PYRIMIDINE-2-CARBOHYDRAZIDE
• 4-Pyrimidinemethanamine, 2-methyl- (9CI)
• 5-Pyrimidinemethanamine, 4-amino- (9CI)
• 4-Pyrimidinemethanamine, 2-chloro- (9CI)
• 4-Pyrimidinemethanamine, alpha-methyl- (9CI)