20-ETHYL PROSTAGLANDIN E2 Chemical Properties

Boiling point:

550.6±50.0 °C(Predicted)

Density 

1.119±0.06 g/cm3(Predicted)

solubility 

DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 125 μg/ml

pka

4.75±0.10(Predicted)

20-ETHYL PROSTAGLANDIN E2 Usage And Synthesis

Description

20-ethyl Prostaglandin E₂ (20-ethyl PGE₂) is an analog of PGE₂ in which the ω-chain has been extended by the addition of two methylene carbon atoms. The only well studied prostaglandin analog with this structural feature is unoprostone, an F-series prostaglandin that is clinically approved as a glaucoma medication. Unoprostone also contains lower side chain modifications (13,14-dihydro-15-keto) which severely limit its affinity for FP receptors, contributing to its lack of potency as a medication. 20-ethyl PGE₂ retains the natural 15(S) allylic hydroxyl in the lower side chain, which may improve its potency relative to unoprostone. However, ligand binding assays of this analog with respect to EP or other prostanoid receptors have not been published. E-type prostaglandins have been widely reported to have inflammatory, cytoprotective, and a variety of other effects.

Uses

20-Ethyl prostaglandin E2 (compound 62) is a PG analog that stimulates Nurr1-dependent transcriptional activity[1].

Definition

ChEBI: 20-Ethyl-PGE2 is a prostanoid.

References

[1] Cheolhwan Yoon, et al. Prostaglandin analogs and uses thereof. US20210139435A1. 2020.

20-ETHYL PROSTAGLANDIN E2(37492-24-3)Related Product Information

• 11-DEOXY PROSTAGLANDIN E2
• Prostaglandin E2
• 20-ETHYL PROSTAGLANDIN E2