11-DEOXY PROSTAGLANDIN E2 Chemical Properties

Boiling point:

510.3±45.0 °C(Predicted)

Density 

1.085±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: >100 mg/ml (from PGE2); DMSO: >100 mg/ml (from PGE2); Ethanol: >100 mg/ml (from PGE2); PBS pH 7.2: >5 mg/ml (from PGE2)

form 

A crystalline solid

pka

4.75±0.10(Predicted)

color 

White to off-white

11-DEOXY PROSTAGLANDIN E2 Usage And Synthesis

Description

11-deoxy Prostaglandin E₂ (11-deoxy PGE₂) is a stable, synthetic analog of PGE₂ . In contrast to PGE₂ which has bronchodilation effects, 11-deoxy PGE₂ is a powerful bronchoconstrictor and contracts human respiratory tract smooth muscle with potencies ranging from 5 to 30 times higher than PGF_2α .

Uses

11-Deoxy Prostaglandin E2 is a selective agonist of EP4 with an EC50 of 0.66 nM. 11-Deoxy Prostaglandin E2 is an analog of prostaglandin E2. 11-Deoxy Prostaglandin E2 can be used in study bone healing, heart failure, and other receptor associated conditions[1][2].

Definition

ChEBI: 11-Deoxy-PGE2 is a prostanoid.

References

[1] Holt MC, et al. Improved homology modeling of the human & rat EP4 prostanoid receptors. BMC Mol Cell Biol. 2019 Aug 27;20(1):37. DOI:10.1186/s12860-019-0212-5
[2] Ungrin MD, et al. Key structural features of prostaglandin E(2) and prostanoid analogs involved in binding and activation of the human EP(1) prostanoid receptor. Mol Pharmacol. 2001 Jun;59(6):1446-56. DOI:10.1124/mol.59.6.1446

11-DEOXY PROSTAGLANDIN E2(35536-53-9)Related Product Information

• Prostaglandin E2
• PROSTAGLANDINS E2 METHYL ESTER
• 11BETA-PROSTAGLANDIN E2
• 9,11-DIOXO-15S-HYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID
• 9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, (4-ACETYLAMINO) PHENYL ESTER
• 9-OXO-11ALPHA-15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC-3,3,4,4-D4 ACID
• 16,16-DIMETHYL PGE2 4-(4-ACETAMIDOBENZAMIDO) PHENYL ESTER
• 11-DEOXY PROSTAGLANDIN E2
• 20-ETHYL PROSTAGLANDIN E2
• 9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, (4-BENZOYLAMINO) PHENYL ESTER
• 9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER
• 15(S)-15-METHYL PROSTAGLANDIN E2
• 19(R)-HYDROXY PROSTAGLANDIN E2
• 20-HYDROXY PROSTAGLANDIN E2
• 11-DEOXY-16,16-DIMETHYL PROSTAGLANDIN E2
• TRIMOPROSTIL
• PGE2, [5,6,8,11,12,14,15-3H]
• PGE2 [1-14C]