11-DEOXY-16,16-DIMETHYL PROSTAGLANDIN E2 Chemical Properties

solubility 

DMF: >100 mg/ml (from PGE2); DMSO: >100 mg/ml (from PGE2); Ethanol: >100 mg/ml (from PGE2); PBS pH 7.2: >5 mg/ml (from PGE2)

11-DEOXY-16,16-DIMETHYL PROSTAGLANDIN E2 Usage And Synthesis

Description

11-deoxy-16,16-dimethyl PGE₂ is a stable synthetic analog of PGE₂. It is an agonist for both EP₂ and EP₃ receptors. It is an effective inhibitor of gastric acid secretion and ulcer formation in the rat, with ED₅₀ values of 1 mg/kg and 0.021 mg/kg respectively. It is 900 times more potent than PGF_2α in the contraction of human respiratory tract smooth muscle in vitro.

Uses

AY 24609 is an analogue of PGE2 and a selective EP2 and EP3 receptors agonist. It also inhibits gastric acid secretion and ulcer formation in rat.

Definition

ChEBI: 11-Deoxy-16,16-dimethyl-PGE2 is a prostanoid.

11-DEOXY-16,16-DIMETHYL PROSTAGLANDIN E2(53658-98-3)Related Product Information

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