16,16-DIMETHYL PROSTAGLANDIN E2
16,16-DIMETHYL PROSTAGLANDIN E2 Basic information
- Product Name:
- 16,16-DIMETHYL PROSTAGLANDIN E2
- Synonyms:
-
- 16,16-DIMETHYL PROSTAGLANDIN E2
- (5z,11-alpha,13e,15r)-11,15-dihydroxy-16,16-dimethyl-9-oxoprosta-5,13-dien-1
- QAOBBBBDJSWHMU-WMBBNPMCSA-N
- 15r)-13e
- 16,16-dimethyl-pge2
- 5-heptenoicacid,7-(2-(4,4-dimethyl-3-hydroxy-1-octenyl)-3-hydroxy-5-oxocycl
- opentyl)-
- prosta-5,13-dien-1-oicacid,11,15-dihydroxy-16,16-dimethyl-9-oxo-,(5z,11-alph
- CAS:
- 39746-25-3
- MF:
- C22H36O5
- MW:
- 380.52
- Product Categories:
-
- Fatty Acids
- Lipids
- Prostaglandins
- Mol File:
- 39746-25-3.mol
16,16-DIMETHYL PROSTAGLANDIN E2 Chemical Properties
- Flash point:
- -13℃
- storage temp.
- -20°C
- solubility
- Soluble in methyl acetate
- form
- methyl acetate solution
Safety Information
- Hazard Codes
- F,Xn,Xi
- Risk Statements
- 11-20/21/22-36/37/38-67-66-36
- Safety Statements
- 16-26-36
- RIDADR
- UN 1231 3/PG 2
- WGK Germany
- 3
MSDS
- Language:English Provider:SigmaAldrich
16,16-DIMETHYL PROSTAGLANDIN E2 Usage And Synthesis
Description
16,16-dimethyl PGE2 is a competitive inhibitor of 15-
Definition
ChEBI: 16,16-dimethylprostaglandin E2 is a prostanoid that is prostaglandin E2 in which both of the hydrogens at position 16 have been replaced by methyl groups. A synthetic analogue of prostaglandin E2, it is a potent inhibitor of pancreatic function and growth of experimental tumors. It also protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. It has a role as a radiation protective agent, an anti-ulcer drug and a gastrointestinal drug. It is a prostanoid, a monocarboxylic acid, a secondary allylic alcohol and a member of cyclopentanones.
in vitro
dmpge2 was reported to cause an increase in runx11/cmyb1 hscs, while hscs were inhibited by indomethacin treatment in 90% of embryos. moreover, dmpge2 had minimal effects on the vasculature, while indomethacin altered the intersomitic vessels slightly. imaged by confocal microscopy, red-labelled hscs and endothelium embryos showed significantly increased hscs following dmpge2 exposure [1].
in vivo
in a heterotopic model of rat allograft rejection, dmpge2 could delay the rejection onset, but all animals developed severe rejection and died subsequently. treatment of animals with low-dose csa in combination with dmpge2 led to a delay in the onset as well as a reduction in the intensity of allograft rejection. in addition, a statistical relationship between procoagulant activity levels and the time of onset of rejection was observed [1].
storage
Store at -80°C
References
[1] north te,goessling w,walkley cr,lengerke c,kopani kr,lord am,weber gj,bowman tv,jang ih,grosser t,fitzgerald ga,daley gq,orkin sh,zon li. prostaglandin e2 regulates vertebrate haematopoietic stem cell homeostasis. nature.2007 jun 21;447(7147):1007-11.
[2] koh ih,kim pc,chung sw,waddell t,wong py,gorczynski r,levy ga,cohen z. the effects of 16, 16 dimethyl prostaglandin e2 therapy alone and in combination with low-dose cyclosporine on rat small intestinal transplantation. transplantation.1992 oct;54(4):592-8.
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16,16-DIMETHYL PROSTAGLANDIN E2(39746-25-3)Related Product Information
- 9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2, POTASSIUM SALT
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- 16,16-DIMETHYL PROSTAGLANDIN D2
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- 16,16-DIMETHYL PROSTAGLANDIN A1
- 16,16-DIMETHYL PROSTAGLANDIN F2ALPHA
- 16,16-DIMETHYL PROSTAGLANDIN E1
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- 16,16-DIMETHYL PROSTAGLANDIN E2 P-(P-ACETAMIDOBENZAMIDO) PHENYL ESTER
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