16,16-DIMETHYL PROSTAGLANDIN E2
- Product Name
- 16,16-DIMETHYL PROSTAGLANDIN E2
- CAS No.
- 39746-25-3
- Chemical Name
- 16,16-DIMETHYL PROSTAGLANDIN E2
- Synonyms
- 15r)-13e;opentyl)-;16-dimethyl PGE2;16,16-dimethyl-pge2;QAOBBBBDJSWHMU-WMBBNPMCSA-N;16,16-Dimethyl dinoprostone;Suppliedasayellow,viscousoil;16-Dimethyl prostaglandin E2;16,16-DimethylprostaglandineE2;16,16-DIMETHYL PROSTAGLANDIN E2
- CBNumber
- CB9416741
- Molecular Formula
- C22H36O5
- Formula Weight
- 380.52
- MOL File
- 39746-25-3.mol
16,16-DIMETHYL PROSTAGLANDIN E2 Property
- Flash point:
- -13℃
- storage temp.
- -20°C
- solubility
- Soluble in methyl acetate
- form
- methyl acetate solution
Safety
- Hazard Codes
- F,Xn,Xi
- Risk Statements
- 11-20/21/22-36/37/38-67-66-36
- Safety Statements
- 16-26-36
- RIDADR
- UN 1231 3/PG 2
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
H336May cause drowsiness or dizziness
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D0160
- Product name
- 16,16-Dimethylprostaglandin E2
- Purity
- methyl acetate solution
- Packaging
- 1mg
- Price
- $348
- Updated
- 2023/06/20
- Product number
- 14750
- Product name
- 16,16-dimethyl Prostaglandin E2
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 14750
- Product name
- 16,16-dimethyl Prostaglandin E2
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $399
- Updated
- 2024/03/01
- Product number
- 14750
- Product name
- 16,16-dimethyl Prostaglandin E2
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $755
- Updated
- 2024/03/01
- Product number
- 4027
- Product name
- 16,16-Dimethylprostaglandin E2
- Purity
- ≥98%(HPLC)
- Packaging
- 1
- Price
- $125
- Updated
- 2021/12/16
16,16-DIMETHYL PROSTAGLANDIN E2 Chemical Properties,Usage,Production
Description
16,16-dimethyl PGE2 is a competitive inhibitor of 15-
Definition
ChEBI: 16,16-dimethylprostaglandin E2 is a prostanoid that is prostaglandin E2 in which both of the hydrogens at position 16 have been replaced by methyl groups. A synthetic analogue of prostaglandin E2, it is a potent inhibitor of pancreatic function and growth of experimental tumors. It also protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. It has a role as a radiation protective agent, an anti-ulcer drug and a gastrointestinal drug. It is a prostanoid, a monocarboxylic acid, a secondary allylic alcohol and a member of cyclopentanones.
in vitro
dmpge2 was reported to cause an increase in runx11/cmyb1 hscs, while hscs were inhibited by indomethacin treatment in 90% of embryos. moreover, dmpge2 had minimal effects on the vasculature, while indomethacin altered the intersomitic vessels slightly. imaged by confocal microscopy, red-labelled hscs and endothelium embryos showed significantly increased hscs following dmpge2 exposure [1].
in vivo
in a heterotopic model of rat allograft rejection, dmpge2 could delay the rejection onset, but all animals developed severe rejection and died subsequently. treatment of animals with low-dose csa in combination with dmpge2 led to a delay in the onset as well as a reduction in the intensity of allograft rejection. in addition, a statistical relationship between procoagulant activity levels and the time of onset of rejection was observed [1].
storage
Store at -80°C
References
[1] north te,goessling w,walkley cr,lengerke c,kopani kr,lord am,weber gj,bowman tv,jang ih,grosser t,fitzgerald ga,daley gq,orkin sh,zon li. prostaglandin e2 regulates vertebrate haematopoietic stem cell homeostasis. nature.2007 jun 21;447(7147):1007-11.
[2] koh ih,kim pc,chung sw,waddell t,wong py,gorczynski r,levy ga,cohen z. the effects of 16, 16 dimethyl prostaglandin e2 therapy alone and in combination with low-dose cyclosporine on rat small intestinal transplantation. transplantation.1992 oct;54(4):592-8.
16,16-DIMETHYL PROSTAGLANDIN E2 Preparation Products And Raw materials
Raw materials
Preparation Products
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