ChemicalBook > CAS DataBase List > 16,16-DIMETHYL PROSTAGLANDIN E2

16,16-DIMETHYL PROSTAGLANDIN E2

Product Name
16,16-DIMETHYL PROSTAGLANDIN E2
CAS No.
39746-25-3
Chemical Name
16,16-DIMETHYL PROSTAGLANDIN E2
Synonyms
15r)-13e;opentyl)-;16-dimethyl PGE2;16,16-dimethyl-pge2;QAOBBBBDJSWHMU-WMBBNPMCSA-N;16,16-Dimethyl dinoprostone;Suppliedasayellow,viscousoil;16-Dimethyl prostaglandin E2;16,16-DimethylprostaglandineE2;16,16-DIMETHYL PROSTAGLANDIN E2
CBNumber
CB9416741
Molecular Formula
C22H36O5
Formula Weight
380.52
MOL File
39746-25-3.mol
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16,16-DIMETHYL PROSTAGLANDIN E2 Property

Flash point:
-13℃
storage temp. 
-20°C
solubility 
Soluble in methyl acetate
form 
methyl acetate solution
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Safety

Hazard Codes 
F,Xn,Xi
Risk Statements 
11-20/21/22-36/37/38-67-66-36
Safety Statements 
16-26-36
RIDADR 
UN 1231 3/PG 2
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D0160
Product name
16,16-Dimethylprostaglandin E2
Purity
methyl acetate solution
Packaging
1mg
Price
$348
Updated
2023/06/20
Cayman Chemical
Product number
14750
Product name
16,16-dimethyl Prostaglandin E2
Purity
≥98%
Packaging
1mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
14750
Product name
16,16-dimethyl Prostaglandin E2
Purity
≥98%
Packaging
5mg
Price
$399
Updated
2024/03/01
Cayman Chemical
Product number
14750
Product name
16,16-dimethyl Prostaglandin E2
Purity
≥98%
Packaging
10mg
Price
$755
Updated
2024/03/01
Tocris
Product number
4027
Product name
16,16-Dimethylprostaglandin E2
Purity
≥98%(HPLC)
Packaging
1
Price
$125
Updated
2021/12/16
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16,16-DIMETHYL PROSTAGLANDIN E2 Chemical Properties,Usage,Production

Description

16,16-dimethyl PGE2 is a competitive inhibitor of 15-hydroxy PGDH, but it is not a substrate for the enzyme. Because of its resistance to metabolism by 15-hydroxy PGDH, it has a prolonged half-life in vivo. 16,16-dimethyl PGE2 acts as an agonist on most EP receptor subtypes, and has been used experimentally to induce cervical ripening, uterine contraction, and prevent ulceration of the gastric mucosa in rats and dogs. The Kd for activation of isolated EP2 receptors is about 1 nM. 16,16-dimethyl PGE2 can be used to preserve the self-renewal properties while preventing the differentiation of hematopoietic stem cells during expansion in culture.

Definition

ChEBI: 16,16-dimethylprostaglandin E2 is a prostanoid that is prostaglandin E2 in which both of the hydrogens at position 16 have been replaced by methyl groups. A synthetic analogue of prostaglandin E2, it is a potent inhibitor of pancreatic function and growth of experimental tumors. It also protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. It has a role as a radiation protective agent, an anti-ulcer drug and a gastrointestinal drug. It is a prostanoid, a monocarboxylic acid, a secondary allylic alcohol and a member of cyclopentanones.

in vitro

dmpge2 was reported to cause an increase in runx11/cmyb1 hscs, while hscs were inhibited by indomethacin treatment in 90% of embryos. moreover, dmpge2 had minimal effects on the vasculature, while indomethacin altered the intersomitic vessels slightly. imaged by confocal microscopy, red-labelled hscs and endothelium embryos showed significantly increased hscs following dmpge2 exposure [1].

in vivo

in a heterotopic model of rat allograft rejection, dmpge2 could delay the rejection onset, but all animals developed severe rejection and died subsequently. treatment of animals with low-dose csa in combination with dmpge2 led to a delay in the onset as well as a reduction in the intensity of allograft rejection. in addition, a statistical relationship between procoagulant activity levels and the time of onset of rejection was observed [1].

storage

Store at -80°C

References

[1] north te,goessling w,walkley cr,lengerke c,kopani kr,lord am,weber gj,bowman tv,jang ih,grosser t,fitzgerald ga,daley gq,orkin sh,zon li. prostaglandin e2 regulates vertebrate haematopoietic stem cell homeostasis. nature.2007 jun 21;447(7147):1007-11.
[2] koh ih,kim pc,chung sw,waddell t,wong py,gorczynski r,levy ga,cohen z. the effects of 16, 16 dimethyl prostaglandin e2 therapy alone and in combination with low-dose cyclosporine on rat small intestinal transplantation. transplantation.1992 oct;54(4):592-8.

16,16-DIMETHYL PROSTAGLANDIN E2 Preparation Products And Raw materials

Raw materials

Preparation Products

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16,16-DIMETHYL PROSTAGLANDIN E2 Suppliers

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39746-25-3, 16,16-DIMETHYL PROSTAGLANDIN E2Related Search:

9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2, POTASSIUM SALT 16,16-DIMETHYL PROSTAGLANDIN A2 16,16-DIMETHYL PROSTAGLANDIN F2BETA 16,16-DIMETHYL PROSTAGLANDIN D2 9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2 16,16-DIMETHYL PROSTAGLANDIN A1 16,16-DIMETHYL PROSTAGLANDIN F2ALPHA 16,16-DIMETHYL PROSTAGLANDIN E1 11-DEOXY-16,16-DIMETHYL PROSTAGLANDIN E2 16,16-DIMETHYL PROSTAGLANDIN E2 P-(P-ACETAMIDOBENZAMIDO) PHENYL ESTER 16,16-DIMETHYL PROSTAGLANDIN E2

  • 16,16-DIMETHYL PROSTAGLANDIN E2
  • (5z,11-alpha,13e,15r)-11,15-dihydroxy-16,16-dimethyl-9-oxoprosta-5,13-dien-1
  • QAOBBBBDJSWHMU-WMBBNPMCSA-N
  • 15r)-13e
  • 16,16-dimethyl-pge2
  • 5-heptenoicacid,7-(2-(4,4-dimethyl-3-hydroxy-1-octenyl)-3-hydroxy-5-oxocycl
  • opentyl)-
  • prosta-5,13-dien-1-oicacid,11,15-dihydroxy-16,16-dimethyl-9-oxo-,(5z,11-alph
  • 16,16-DimethylprostaglandineE2
  • Suppliedasayellow,viscousoil
  • 16,16-DIMETHYL PROSTAGLANDIN E2 SUPPLIED AS A YELLOW, VISCOUS OIL
  • (5Z,13E,15R)-11α,15-Dihydroxy-16,16-dimethyl-9-oxoprosta-5,13-dien-1-oic acid
  • 16,16-Dimethyl dinoprostone
  • (5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxo-prosta-5,13-dien-1oicacid
  • 9-OXO-11ALPHA,15R-DIHYDROXY-16,16-DIMETHYL-PROSTA-5Z,13E-DIEN-1-OIC ACID
  • Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, (5Z,11α,13E,15R)-
  • 16,16-Dimethylprostaglandin E2 methyl acetate solution
  • 16-dimethyl PGE2
  • 16-Dimethyl prostaglandin E2
  • 16,16 Dimethyl prostaglandin E2,16,16Dimethyl prostaglandin E2,16,16-Dimethyl prostaglandin E-2
  • (5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-diMethyl-9-oxo-prosta-5,13-dien-1oicacid
  • 16,16-Dimethylprostaglandin E2, 15-hydroxy PGDH inhibitor
  • 39746-25-3
  • C22H36O5
  • Biochemicals and Reagents
  • Lipids
  • Fatty Acids
  • Prostaglandins
  • BioChemical
  • Fatty Acids
  • Lipids
  • Prostaglandins