ChemicalBook > CAS DataBase List > 16,16-DIMETHYL PROSTAGLANDIN E2

16,16-DIMETHYL PROSTAGLANDIN E2

Product Name: 16,16-DIMETHYL PROSTAGLANDIN E2
CAS No.: 39746-25-3
Chemical Name: 16,16-DIMETHYL PROSTAGLANDIN E2
Synonyms: 15r)-13e;opentyl)-;16-dimethyl PGE2;16,16-dimethyl-pge2;QAOBBBBDJSWHMU-WMBBNPMCSA-N;16,16-Dimethyl dinoprostone;Suppliedasayellow,viscousoil;16-Dimethyl prostaglandin E2;16,16-DimethylprostaglandineE2;16,16-DIMETHYL PROSTAGLANDIN E2
CBNumber: CB9416741
Molecular Formula: C22H36O5
Formula Weight: 380.52
MOL File: 39746-25-3.mol

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16,16-DIMETHYL PROSTAGLANDIN E2 Property

Flash point:: -13℃
storage temp.: -20°C
solubility: Soluble in methyl acetate
form: methyl acetate solution
color: Colorless to light yellow
biological source: synthetic (organic)

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Safety

Hazard Codes: F,Xn,Xi
Risk Statements: 11-20/21/22-36/37/38-67-66-36
Safety Statements: 16-26-36
RIDADR: UN 1231 3/PG 2
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D0160
Product name: 16,16-Dimethylprostaglandin E2
Purity: methyl acetate solution
Packaging: 1mg
Price: $348
Updated: 2023/06/20

Cayman Chemical

Product number: 14750
Product name: 16,16-dimethyl Prostaglandin E2
Purity: ≥98%
Packaging: 1mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 14750
Product name: 16,16-dimethyl Prostaglandin E2
Purity: ≥98%
Packaging: 5mg
Price: $399
Updated: 2024/03/01

Cayman Chemical

Product number: 14750
Product name: 16,16-dimethyl Prostaglandin E2
Purity: ≥98%
Packaging: 10mg
Price: $755
Updated: 2024/03/01

Tocris

Product number: 4027
Product name: 16,16-Dimethylprostaglandin E2
Purity: ≥98%(HPLC)
Packaging: 1
Price: $125
Updated: 2021/12/16

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16,16-DIMETHYL PROSTAGLANDIN E2 Chemical Properties,Usage,Production

Description

16,16-dimethyl PGE₂ is a competitive inhibitor of 15-hydroxy PGDH, but it is not a substrate for the enzyme. Because of its resistance to metabolism by 15-hydroxy PGDH, it has a prolonged half-life in vivo. 16,16-dimethyl PGE₂ acts as an agonist on most EP receptor subtypes, and has been used experimentally to induce cervical ripening, uterine contraction, and prevent ulceration of the gastric mucosa in rats and dogs. The K_d for activation of isolated EP₂ receptors is about 1 nM. 16,16-dimethyl PGE₂ can be used to preserve the self-renewal properties while preventing the differentiation of hematopoietic stem cells during expansion in culture.

Definition

ChEBI: 16,16-dimethylprostaglandin E2 is a prostanoid that is prostaglandin E2 in which both of the hydrogens at position 16 have been replaced by methyl groups. A synthetic analogue of prostaglandin E2, it is a potent inhibitor of pancreatic function and growth of experimental tumors. It also protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. It has a role as a radiation protective agent, an anti-ulcer drug and a gastrointestinal drug. It is a prostanoid, a monocarboxylic acid, a secondary allylic alcohol and a member of cyclopentanones.

in vitro

dmpge2 was reported to cause an increase in runx11/cmyb1 hscs, while hscs were inhibited by indomethacin treatment in 90% of embryos. moreover, dmpge2 had minimal effects on the vasculature, while indomethacin altered the intersomitic vessels slightly. imaged by confocal microscopy, red-labelled hscs and endothelium embryos showed significantly increased hscs following dmpge2 exposure [1].

in vivo

in a heterotopic model of rat allograft rejection, dmpge2 could delay the rejection onset, but all animals developed severe rejection and died subsequently. treatment of animals with low-dose csa in combination with dmpge2 led to a delay in the onset as well as a reduction in the intensity of allograft rejection. in addition, a statistical relationship between procoagulant activity levels and the time of onset of rejection was observed [1].

storage

Store at -80°C

References

[1] north te,goessling w,walkley cr,lengerke c,kopani kr,lord am,weber gj,bowman tv,jang ih,grosser t,fitzgerald ga,daley gq,orkin sh,zon li. prostaglandin e2 regulates vertebrate haematopoietic stem cell homeostasis. nature.2007 jun 21;447(7147):1007-11.
[2] koh ih,kim pc,chung sw,waddell t,wong py,gorczynski r,levy ga,cohen z. the effects of 16, 16 dimethyl prostaglandin e2 therapy alone and in combination with low-dose cyclosporine on rat small intestinal transplantation. transplantation.1992 oct;54(4):592-8.

16,16-DIMETHYL PROSTAGLANDIN E2 Preparation Products And Raw materials

Raw materials

Preparation Products

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39746-25-3, 16,16-DIMETHYL PROSTAGLANDIN E2Related Search:

9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2, POTASSIUM SALT 16,16-DIMETHYL PROSTAGLANDIN A2 16,16-DIMETHYL PROSTAGLANDIN F2BETA 16,16-DIMETHYL PROSTAGLANDIN D2 9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2 16,16-DIMETHYL PROSTAGLANDIN A1 16,16-DIMETHYL PROSTAGLANDIN F2ALPHA 16,16-DIMETHYL PROSTAGLANDIN E1 11-DEOXY-16,16-DIMETHYL PROSTAGLANDIN E2 16,16-DIMETHYL PROSTAGLANDIN E2 P-(P-ACETAMIDOBENZAMIDO) PHENYL ESTER 16,16-DIMETHYL PROSTAGLANDIN E2

16,16-DIMETHYL PROSTAGLANDIN E2

(5z,11-alpha,13e,15r)-11,15-dihydroxy-16,16-dimethyl-9-oxoprosta-5,13-dien-1

QAOBBBBDJSWHMU-WMBBNPMCSA-N

15r)-13e

16,16-dimethyl-pge2

5-heptenoicacid,7-(2-(4,4-dimethyl-3-hydroxy-1-octenyl)-3-hydroxy-5-oxocycl

opentyl)-

prosta-5,13-dien-1-oicacid,11,15-dihydroxy-16,16-dimethyl-9-oxo-,(5z,11-alph

16,16-DimethylprostaglandineE2

Suppliedasayellow,viscousoil

16,16-DIMETHYL PROSTAGLANDIN E2 SUPPLIED AS A YELLOW, VISCOUS OIL

(5Z,13E,15R)-11α,15-Dihydroxy-16,16-dimethyl-9-oxoprosta-5,13-dien-1-oic acid

16,16-Dimethyl dinoprostone

(5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxo-prosta-5,13-dien-1oicacid

9-OXO-11ALPHA,15R-DIHYDROXY-16,16-DIMETHYL-PROSTA-5Z,13E-DIEN-1-OIC ACID

Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, (5Z,11α,13E,15R)-

16,16-Dimethylprostaglandin E2 methyl acetate solution

16-dimethyl PGE2

16-Dimethyl prostaglandin E2

16,16 Dimethyl prostaglandin E2,16,16Dimethyl prostaglandin E2,16,16-Dimethyl prostaglandin E-2

16,16-Dimethylprostaglandin E2, 15-hydroxy PGDH inhibitor

16,16-Dimethylprostaglandin E<sub>2</sub>

Prosta-5,13-dien-1-oicacid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, (5Z,11a,13E,15R)-

39746-25-3

C22H36O5

Biochemicals and Reagents

Lipids

Fatty Acids

Prostaglandins

BioChemical

Fatty Acids

Lipids

Prostaglandins