9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2
9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2 Basic information
- Product Name:
- 9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2
- Synonyms:
-
- 9-METHYLENE-11ALPHA,15R-DIHYDROXY-16,16-DIMETHYL-PROSTA-5Z,13E-DIEN-1-OIC ACID
- 9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2
- METENPROST
- 9-Deoxo-9-Methylene-16,16-diMethyl-PGE2
- 9-Deoxy-16,16-diMethyl-9-Methylene-PGF2
- U 46785
- 5-heptenoicacid,7-(5,5-dimethyl-3-hydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)
- 7-(5,5-dimethyl-3-hydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoicaci
- CAS:
- 61263-35-2
- MF:
- C23H38O4
- MW:
- 378.55
- Product Categories:
-
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 61263-35-2.mol
9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2 Chemical Properties
- Boiling point:
- 426.61°C (rough estimate)
- Density
- 1.0037 (rough estimate)
- refractive index
- 1.4433 (estimate)
- storage temp.
- Store at -20°C
- solubility
- DMF: >100 mg/ml (from PGE2); DMSO: >100 mg/ml (from PGE2); Ethanol: >100 mg/ml (from PGE2); PBS pH 7.2: >5 mg/ml (from PGE2)
- pka
- 4.76±0.10(Predicted)
9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2 Usage And Synthesis
Uses
9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (Meteneprost) is a potent analog of prostaglandin E2 (PGE2; ) with an extended half-life in vivo. In combination with various other prostaglandin derivatives, it results in the termination of first trimester pregnancy in monkeys. A single intramuscular injection containing 0.5 mg of meteneprost and 7.5 mg of 17-phenyl trinor PGF1α is very effective in terminating early pregnancy. This prostaglandin mixture is ineffective on monkeys in their third trimester of pregnancy. Meteneprost, when compared to PGE2 and PGF1α, in monkey and rat, does not result in unwanted side effects such as fever or gastrointestinal problems.
Uses
Meteneprost is a potent analog of Prostaglandin E2 (PGE2) (P838610). Meteneprost in combination with various other prostaglandin derivatives is used for medical termination of early pregnancy.
Definition
ChEBI: 9-Deoxy-9-methylene-16,16-dimethyl -PGE2 is a long-chain fatty acid.
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