16,16-DIMETHYL PROSTAGLANDIN F2ALPHA
16,16-DIMETHYL PROSTAGLANDIN F2ALPHA Basic information
- Product Name:
- 16,16-DIMETHYL PROSTAGLANDIN F2ALPHA
- Synonyms:
-
- 16,16-DIMETHYL PROSTAGLANDIN F2ALPHA
- 9ALPHA,11ALPHA,15R-TRIHYDROXY-16,16-DIMETHYL-PROSTA-5Z,13E-DIEN-1-OIC ACID
- 16,16-dimethylprostaglandin F2A
- 16,16-dimethyl Prostaglandin F2α
- YMRWVEHSLXJOCD-SCOYTADVSA-N
- Prosta-5,13-dien-1-oicacid, 9,11,15-trihydroxy-16,16-dimethyl-, (5Z,9a,11a,13E,15R)- (9CI)
- CAS:
- 39746-23-1
- MF:
- C22H38O5
- MW:
- 382.53
- Mol File:
- 39746-23-1.mol
16,16-DIMETHYL PROSTAGLANDIN F2ALPHA Chemical Properties
- Flash point:
- -13 °C
- storage temp.
- -20°C
- solubility
- 10 mM Na2CO3: >6.5 mg/ml; DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/ml; PBS pH 7.2: >10 mg/ml
- form
- A crystalline solid
Safety Information
- Hazard Codes
- F,Xi
- Risk Statements
- 11-36-66-67
- Safety Statements
- 16-26-29-33
16,16-DIMETHYL PROSTAGLANDIN F2ALPHA Usage And Synthesis
Uses
16,16-Dimethylprostaglandin F2α (16,16-Dimethyl-PGF2α) is a potent analog of PGF2α (HY-12956), which exhibits similar binding potency as PGF2α does. 16,16-Dimethylprostaglandin F2α serves as a bronchoconstrictor[1][2].
in vivo
16,16-Dimethylprostaglandin F2α (0-0.5 μg, iv, single dose) inhibits histamine-induced intracheal insufflation pressure increase in guinea pigs model.
| Animal Model: | guinea pigs model[1] |
| Dosage: | 0-0.5 μg |
| Administration: | iv, single dose |
| Result: | Inhibited histamine-induced increase in tracheal insufflation pressure. |
References
[1] Strandberg K, et al., Bronchial effects of some prostaglandin E and F analogues. Acta Physiol Scand. 1977 Jun;100(2):172-81. DOI:10.1111/j.1748-1716.1977.tb05934.x
[2] Balapure AK, et al., Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2 alpha receptor. Implications for development of a photoaffinity probe. Biochem Pharmacol. 1989 Jul 15;38(14):2375-81. DOI:10.1016/0006-2952(89)90478-4
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