11-DEOXY PROSTAGLANDIN F2ALPHA Chemical Properties

Boiling point:

511.4±45.0 °C(Predicted)

Density 

1.090±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

10 mM Na2CO3: >6.5 mg/ml (from PGF2a); DMF: >100 mg/ml (from PGF2a); DMSO: >100 mg/ml (from PGF2a); Ethanol: >100 mg/ml (from PGF2a); PBS pH 7.2: >10 mg/ml (from PGF2a)

pka

4.76±0.10(Predicted)

11-DEOXY PROSTAGLANDIN F2ALPHA Usage And Synthesis

Description

11-deoxy PGF_2α is a synthetic analog of PGF_2α. It is a more potent agonist than PGF_2α at inducing smooth muscle contractions of rabbit aorta, dog saphenous vein, and guinea pig trachea. It is approximately 20% less potent than U-46619.

Uses

11-Deoxyprostaglandin F2α is an activator for TREK-2 channels with EC50 of 0.294 μM. 11-Deoxyprostaglandin F2α inhibits the K2P channel TREK-1[1].

References

[1] Dadi PK,et al., Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx. ACS Chem Neurosci. 2017 Mar 15;8(3):558-568. DOI:10.1021/acschemneuro.6b00301

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