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PROSTAGLANDIN D2

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PROSTAGLANDIN D2 Basic information

Product Name:
PROSTAGLANDIN D2
Synonyms:
  • 9,15-dihydroxy-11-oxo-,(5z,9-alpha,13e,15s)-prosta-13-dien-1-oicacid
  • prostaglandin D2 cell culture tested
  • prostaglandind2synthetichygroscopic
  • (5z,9α,13e,15s)-9,15-dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid
  • 7-[(1R,2R,5S)-5-hydroxy-2-[(3S)-3-hydroxyoct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid
  • PGD2, (5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid
  • (5Z,13E,15S)-9α,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic acid
  • Prostaglandin D2,(5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid, PGD2
CAS:
41598-07-6
MF:
C20H32O5
MW:
352.47
EINECS:
636-995-9
Mol File:
41598-07-6.mol
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PROSTAGLANDIN D2 Chemical Properties

Melting point:
68°C
Boiling point:
406.07°C (rough estimate)
alpha 
+7.5°(D/21℃)(c=1,THF)
Density 
1.0601 (rough estimate)
refractive index 
1.6120 (estimate)
storage temp. 
-20°C
solubility 
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly), THF (Slightly)
pka
4.76±0.10(Predicted)
form 
White solid
color 
White to Light Orange
BRN 
2170623
Stability:
Light Sensitive
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Safety Information

Hazard Codes 
T
Risk Statements 
60-22
Safety Statements 
53-22-26-36
WGK Germany 
3
RTECS 
UK7930000
10

MSDS

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PROSTAGLANDIN D2 Usage And Synthesis

Description

Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD2 is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 inhibits human ovarian tumor cell proliferation with an IC50 of 6.8 μM.

Uses

Prostaglandin D2 is a fatty acid compound present in the human body. Elevated levels of localized Prostaglandin D2 has been linked to hair loss and growth inhibition. It has also been seen to contribute to the activity of allergic asthma.

Definition

ChEBI: A member of the class of prostaglandins D that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9 and 15 and an oxo group at position 11 (the 5Z,9alpha,13E,15S- s ereoisomer).

Biochem/physiol Actions

Primary prostaglandin in brain; induces inflammation; stimulates adenylyl cyclase.

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