PROSTAGLANDIN J2 Chemical Properties

Boiling point:

521.7±50.0 °C(Predicted)

Density 

1.103±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

DMF: >100 mg/ml (from PGD2); DMSO: >50 mg/ml (from PGD2); Ethanol: >75 mg/ml (from PGD2); PBS pH 7.2: >2.7 mg/ml (from 15-deoxy-.DEL

pka

4.75±0.10(Predicted)

Safety Information

Hazard Codes 

Xn,Xi,F

Risk Statements 

20/21/22-36/37/38-67-66-36-11

Safety Statements 

26-36-33-29-16

PROSTAGLANDIN J2 Usage And Synthesis

Description

Prostaglandin J₂ (PGJ₂) is formed from PGD₂ by the elimination of the C-9 hydroxyl group, a process which is accelerated by the presence of albumin. PGJ₂ inhibits platelet aggregation with an IC₅₀ of about 5-10 nM. PGJ₂ has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines. However, this activity has been attributed to further metabolites of PGJ₂ and not the parent compound itself.

Uses

PGJ2 (Prostaglandin J2) is a Prostaglandin D2 metabolite that has shown potent anti-neoplastic and antiviral activity.

Definition

ChEBI: A member of the class of prostaglandins J that consists of prosta-5,9,13-trien-1-oic acid substituted by an oxo group at position 11 and a hydroxy group at position 15 (the 5Z,13E,15S stereoisomer).

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