PROSTAGLANDINS E2 METHYL ESTER
PROSTAGLANDINS E2 METHYL ESTER Basic information
- Product Name:
- PROSTAGLANDINS E2 METHYL ESTER
- Synonyms:
-
- 9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, METHYL ESTER
- 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoicacimeth
- pge2methylester
- ylester,stereoisomer
- PROSTAGLANDIN E2 METHYL ESTER
- PROSTAGLANDINS E2 METHYL ESTER
- (5Z)-7-[(1R)-2β-[(1E,3S)-3-Hydroxy-1-octenyl]-3α-hydroxy-5-oxocyclopentane-1α-yl]-5-heptenoic acid methyl ester
- (5Z,13E,15S)-11α,15-Dihydroxy-9-oxo-5,13-prostadiene-1-oic acid methyl ester
- CAS:
- 31753-17-0
- MF:
- C21H34O5
- MW:
- 366.49
- Mol File:
- 31753-17-0.mol
PROSTAGLANDINS E2 METHYL ESTER Chemical Properties
- storage temp.
- −20°C
- solubility
- DMF: >25 mg/ml; DMSO: >30 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: >150 μg/ml
Safety Information
- Hazard Codes
- F,Xn
- Risk Statements
- 11-20/21/22-36/37/38
- Safety Statements
- 16-26-36
- RIDADR
- UN 1231 3/PG 2
- WGK Germany
- 3
MSDS
- Language:English Provider:SigmaAldrich
PROSTAGLANDINS E2 METHYL ESTER Usage And Synthesis
Description
Prostaglandin E2 methyl ester (PGE2 methyl ester) is an analog of PGE2 with enhanced lipid solubility. PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4. Affinity constants (Kd) values of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Uses
Prostaglandin E2 methyl ester (PGE2 methyl ester) is an lipophilic derivative analog of PGE2 (HY-101952). Prostaglandin E2 methyl ester has more central penetration ability than PGE2[1].
References
[1] Strand JC, et al. Biological activity of the methyl esters of prostaglandin E2 and its (15S)-15-methyl analogue. Eur J Pharmacol. 1974 May;26(2):151-7. DOI:10.1016/0014-2999(74)90221-0
PROSTAGLANDINS E2 METHYL ESTERSupplier
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PROSTAGLANDINS E2 METHYL ESTER(31753-17-0)Related Product Information
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- PROSTAGLANDINS E2 METHYL ESTER
- 16,16-DIMETHYL PGE2 4-(4-ACETAMIDOBENZAMIDO) PHENYL ESTER
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