3-broMo-5,7-dichloropyrazolo(1,5-a)pyriMidine Chemical Properties

Melting point:

73-75 °C

Density 

2.16

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-3.17±0.40(Predicted)

Appearance

Yellow to brown Solid

InChI

InChI=1S/C6H2BrCl2N3/c7-3-2-10-12-5(9)1-4(8)11-6(3)12/h1-2H

InChIKey

CJIKMWXLGRVJMI-UHFFFAOYSA-N

SMILES

C12=C(Br)C=NN1C(Cl)=CC(Cl)=N2

3-broMo-5,7-dichloropyrazolo(1,5-a)pyriMidine Usage And Synthesis

Uses

3-Bromo-5,7-dichloro-pyrazolo[1,5-a]pyrimidine is an intermediate used in the synthesis of inhibitors of mitogen-activated protein kinase-activated protein kinase 2 as an antiinflammatory target.

Synthesis

General procedure for the synthesis of 3-bromo-5,7-dichloropyrazolo[1,5-a]pyrimidines from 5,7-dichloropyrazolo[1,5-a]pyrimidines: To a solution of 5,7-dichloropyrazolo[1,5-a]pyrimidines (1 g, 5.32 mmol) in acetonitrile (20 mL) was added N-bromosuccinimide (1.04 g, 5.85 mmol) and ammonium ceric nitrate (0.029 g, 0.053 mmol). The reaction mixture was heated to reflux for 1 hour. After completion of the reaction, the reaction mixture was washed sequentially with 10% aqueous sodium bisulfite (30 mL) and brine (20 mL). The organic phase was dried with magnesium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with 20% ether/hexane as eluent to afford 3-bromo-5,7-dichloropyrazolo[1,5-a]pyrimidine as a yellow solid (1.33 g, 92% yield). δH (400 MHz; d4-CDCl3) 8.22 (1H, s), 7.04 (1H, s).

References

[1] Patent: WO2004/87707, 2004, A1. Location in patent: Page 33; 34
[2] Patent: WO2014/75168, 2014, A1. Location in patent: Page/Page column 53
[3] Patent: WO2015/70349, 2015, A1. Location in patent: Page/Page column 22; 23
[4] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 7, p. 671 - 675
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 15, p. 6700 - 6715

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