(D-ALA7)-ANGIOTENSIN I/II (1-7)
(D-ALA7)-ANGIOTENSIN I/II (1-7) Basic information
- Product Name:
- (D-ALA7)-ANGIOTENSIN I/II (1-7)
- Synonyms:
-
- A-779
- H-ASP-ARG-VAL-TYR-ILE-HIS-D-ALA-OH
- DRVYIHA
- (D-ALA7)-ANGIOTENSIN I/II (1-7)
- ASP-ARG-VAL-TYR-ILE-HIS-D-ALA
- (D-Ala7)-Angiotensin I/II (1-7) A-779
- A 779(3TFA)
- A 779,Asp-Arg-Val-Tyr-Ile-His-d-Ala,DRVYIHd-ALA, >98%
- CAS:
- 159432-28-7
- MF:
- C39H60N12O11
- MW:
- 872.97
- Mol File:
- 159432-28-7.mol
(D-ALA7)-ANGIOTENSIN I/II (1-7) Chemical Properties
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- -15°C
- pka
- 3.29±0.10(Predicted)
- form
- lyophilized powder
- color
- white to off-white
- Water Solubility
- ≥ 29.1mg/mL in Water with gentle warming
- Sequence
- Asp-Arg-Val-Tyr-Ile-His-{d-Ala}
(D-ALA7)-ANGIOTENSIN I/II (1-7) Usage And Synthesis
Uses
A 779 is an angiotensin heptapeptide analog antagonist.
Biochem/physiol Actions
A-779 (D-Ala7-Ang-(1-7)) is a potent and selective antagonist of angiotensin (1-7), an endogenous peptide that acts through activation of a non-AT1, non-AT2 receptor, Mas, and opposes the activity of angiotensin. A-779 has an IC50 of 0.3 nM for Mas with negligible affinity for either AT1R or AT2R.
in vivo
Infusion of Ang(1-7) and A-779 (400 ng/kg/min, s.c.) alone or combined for 6 weeks does not prevent uterus atrophy or inhibit the body weight gain of OVX rats. A-779 markedly elevates serum bone specific alkaline phosphatase (BALP), telopeptides of collagen type I (CTX), tartarate resistant acid phosphatase (TRAcP 5b), osteocalcin (OC) and urinary deoxypyridinoline (DPD). Infusion of Ang(1-7) and/or A-779 does not significantly change serum minerals concentrations in sham or OVX groups. A-779 in the OVX animals does not change AngII, Ang(1-7), AT1R, AT2R, ACE, ACE-2, Mas receptor, RANKL and OPG proteins expressions in relation to OVX group, while AngII (P < 0.05), AT1R (P < 0.05), ACE (P < 0.01) and RANKL (P < 0.01) expressions are significantly higher and Ang(1-7), AT2R, ACE-2, MasR and OPG are significantly (P < 0.01) lower than sham group. Blocking of the G-protein coupled receptor (Mas) by A-779 markedly abolishes Ang(1-7) favorable effects on bone health suggesting the vital role of Mas receptor in mediating Ang(1-7) osteo-protective effects[1]. Inhibition of Ang1-7 cascade by A-779 (400 ng/kg/min) significantly eradicates captopril protective effects on bone metabolism, mineralization and micro-structure. A-779 also restores OVX effects on RANKL expression and ACE-1/AngII/AT1R cascade and down-regulates OPG expression and ACE-2/Ang1-7/Mas pathway[2].
IC 50
AT2 Receptor; AT1 Receptor
storage
Store at -20°C
(D-ALA7)-ANGIOTENSIN I/II (1-7)Supplier
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