SDZ 220-581
SDZ 220-581 Basic information
- Product Name:
- SDZ 220-581
- Synonyms:
-
- (S)-ALPHA-AMINO-2'-CHLORO-5-(PHOSPHONOMETHYL)[1,1'-BIPHENYL]-3-PROPANOIC ACID
- SDZ 220-581
- alpha-Amino-2'-chloro-5-(phosphonomethyl)(1,1'-biphenyl)-3-propanoic acid
- (S)-α-Amino-2'-chloro-5-(phosphonomethyl)[1,1'-biphenyl]-3-propanoicacid
- [1,1'-Biphenyl]-3-propanoic acid, α-amino-2'-chloro-5-(phosphonomethyl)-, (αS)-
- SDZ 220581,SDZ 220 581
- CAS:
- 174575-17-8
- MF:
- C16H17ClNO5P
- MW:
- 369.74
- Product Categories:
-
- Glutamate receptor
- Mol File:
- 174575-17-8.mol
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SDZ 220-581 Chemical Properties
- Boiling point:
- 613.3±65.0 °C(Predicted)
- Density
- 1.478
- storage temp.
- Store at RT
- solubility
- DMSO : 8.57 mg/mL (23.18 mM; Need ultrasonic and warming)
- form
- Powder
- pka
- 1.63±0.10(Predicted)
- color
- Light yellow to yellow
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SDZ 220-581 Usage And Synthesis
Uses
SDZ 220-581 is a competitive NMDA receptor antagonist.
Biological Activity
Competitive NMDA receptor antagonist (pK i = 7.7). Centrally active following oral administration (ED 50 < 3.2 mg/kg for protection against MES-induced seizures).
in vivo
SDZ 220-581 (3.2-32 mg/kg; oral administration; for 24 hours; male OF-l mice) treatment dose-dependently protects mice against maximal electroshock seizures (MES). The time-course of protection by SDZ 220-581 is characterized by a rapid onset and long duration of action[1].
| Animal Model: | Male OF-l mice (18-26 g)[1] |
| Dosage: | 3.2 mg/kg, 10 mg/kg, 32 mg/kg |
| Administration: | Oral administration; for 24 hours |
| Result: | Dose-dependently protected mice against maximal electroshock seizures (MES) upon oral administration. |
IC 50
NMDA Receptor
storage
Store at RT
SDZ 220-581Supplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Atop-Pharma (Shanghai) Technology Co., Ltd.
- Tel
- +86 (21) 5196-9732
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
AdooQ BioScience, LLC
- Tel
- +1 (866) 930-6790
- info@adooq.com
AdooQ Bioscience CHINA
- Tel
- 025-58849295 18951903616;
- info@adooq.cn