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2-Amino-5-chloropyridine

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2-Amino-5-chloropyridine Basic information

Product Name:
2-Amino-5-chloropyridine
Synonyms:
  • 2-Amino-5-chloropyridine 
  • 5-Chloro-2-pyridineamine
  • 5-Chloro-a-aminopyridine
  • 2-Amino-5-chloropyridine ,98%
  • 2-Amino-5-chloropyridine
  • 2-AMINO-5-CHLOROPYRIDINE 5-CHLORO-PYRIDIN-2-YLAMINE
  • 2-Amino-5-chlorophridine
  • 2-AMINO-5-CHLOROPYRIDINE FOR SYNTHESIS
CAS:
1072-98-6
MF:
C5H5ClN2
MW:
128.56
EINECS:
214-020-4
Product Categories:
  • FINE Chemical & INTERMEDIATES
  • Amines
  • PYRIDINE
  • Nitrogen cyclic compounds
  • blocks
  • Heterocycle-Pyridine series
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Pyridines derivates
  • Chloropyridines
  • Halopyridines
  • C5Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • amine| alkyl chloride
  • Bromides
  • Pyridines
  • bc0001
  • 1072-98-6
  • john's
Mol File:
1072-98-6.mol
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2-Amino-5-chloropyridine Chemical Properties

Melting point:
135-138 °C (lit.)
Boiling point:
127-128 °C/11 mmHg (lit.)
Density 
1.2417 (rough estimate)
refractive index 
1.5110 (estimate)
Flash point:
160 °C
storage temp. 
2-8°C
solubility 
1.0g/l
pka
4.67±0.13(Predicted)
form 
Crystalline Powder
color 
Beige to beige-brown
Water Solubility 
1 g/L (20 ºC)
BRN 
108735
InChIKey
MAXBVGJEFDMHNV-UHFFFAOYSA-N
CAS DataBase Reference
1072-98-6(CAS DataBase Reference)
NIST Chemistry Reference
2-Amino-5-chloropyridine(1072-98-6)
EPA Substance Registry System
2-Amino-5-chloropyridine (1072-98-6)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
22-24/25-37/39-26-36
WGK Germany 
3
Hazard Note 
Harmful
HazardClass 
IRRITANT
HS Code 
29333999

MSDS

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2-Amino-5-chloropyridine Usage And Synthesis

Chemical Properties

beige to beige-brown crystalline powder

Uses

5-Chloro-2-pyridinamine is a useful synthetic intermediate. It can be used to synthesize zopiclone (Z700500) which is a cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists.

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 93, 1976 DOI: 10.1021/jo00863a020

Purification Methods

Recrystallise this base from pet ether. It sublimes at 50o/0.5mm. [Beilstein 22 II 332, 22/8 V 541.]

2-Amino-5-chloropyridine Preparation Products And Raw materials

Preparation Products

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