5-Chloro-2-hydroxy-3-nitropyridine Chemical Properties

Melting point:

232-236 °C

Boiling point:

284.1±40.0 °C(Predicted)

Density 

1.61±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

soluble in Dimethylformamide

form 

powder to crystal

pka

6.31±0.10(Predicted)

color 

Light yellow to Yellow to Green

BRN 

383852

CAS DataBase Reference

21427-61-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-41-37/38-22

Safety Statements 

26-36/37/39-39-36-37

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29337900

MSDS

• Language:English Provider:ALFA

5-Chloro-2-hydroxy-3-nitropyridine Usage And Synthesis

Chemical Properties

White to light brown solid

Uses

5-Chloro-2-hydroxy-3-nitropyridine (cas# 21427-61-2) is a compound useful in organic synthesis.

Synthesis

Preparation of Example A2 5-chloro-2-hydroxy-3-nitropyridine (STR9): 321 g of 2-amino-5-chloropyridine was slowly added dropwise to 1.25 L of concentrated sulfuric acid with continuous stirring until the raw material was completely dissolved. Subsequently, 172.5 g of sodium nitrite (dissolved in 240 mL of water) was slowly added at 40°C to 45°C and the reaction mixture continued to be stirred for 15 minutes. Next, 125 mL of pure nitric acid was slowly added dropwise over 40 minutes at 50°C. The reaction mixture was maintained at 55°C for 1 hour and then the reaction was quenched by pouring into 5 kg of ice water. The yellow precipitated product was collected by filtration, washed thoroughly with deionized water and dried at 60°C to afford 351 g of 5-chloro-2-hydroxy-3-nitropyridine in 80.5% of the theoretical yield and a melting point of 229°C to 231°C.

References

[1] Patent: US5274100, 1993, A
[2] Yakugaku Zasshi, 1952, vol. 72, p. 431
[3] Chem.Abstr., 1953, p. 6404

5-Chloro-2-hydroxy-3-nitropyridine(21427-61-2)Related Product Information

• 4-Hydroxy-3-nitropyridine
• 3-Nitropyridine
• Clopidol
• 3-Nitro-2-pyridinol
• Pentachloropyridine
• 2-Bromo-5-nitropyridine
• 3-Hydroxypyridine
• CHLOROPHOSPHONAZO III
• 2-Chloro-3-hydroxypyridine
• 5-CHLORO-3-PYRIDINAMINE
• 2-HYDROXY-3-NITROPYRIDINE
• 3-CHLORO-5-NITROPYRIDINE
• 5-Chloro-2-ethoxy-3-nitropyridine
• 5-CHLORO-2-HYDROXYPYRIDINE
• 5-Chloro-2-methoxy-3-nitropyridine
• 2-Nitrochlorobenzene
• Difluorochloromethane
• 4-Nitrobenzyl chloride