2-Amino-6-chloropyridine Chemical Properties

Melting point:

69-73 °C

Boiling point:

255.7±20.0 °C(Predicted)

Density 

1.326±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

2.76±0.24(Predicted)

form 

Powder or Low Melting Solid

color 

Orange to light brown

BRN 

108669

InChI

InChI=1S/C5H5ClN2/c6-4-2-1-3-5(7)8-4/h1-3H,(H2,7,8)

InChIKey

OBYJTLDIQBWBHM-UHFFFAOYSA-N

SMILES

C1(N)=NC(Cl)=CC=C1

CAS DataBase Reference

45644-21-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

26-36/37-36

WGK Germany 

3

RTECS 

US1813350

Hazard Note 

Harmful/Irritant

HazardClass 

IRRITANT

HS Code 

29333990

MSDS

• Language:English Provider:ALFA

2-Amino-6-chloropyridine Usage And Synthesis

Chemical Properties

White to light yellow powder

Uses

Substrate used in a Ni(II)-catalyzed homo-coupling providing diamino-2,2′-bipyridine.

Uses

2-Amino-6-chloropyridine used in a Ni(II)-catalyzed homo-coupling providing diamino-2,2′-bipyridine.

Synthesis

The general procedure for the synthesis of 2-amino-6-chloropyridine from 2-chloro-6-nitropyridine was as follows: the TAPEHA-Pd catalyst (0.015 g) was added to EtOH/water (1:1, 20 mL) solution containing nitroaromatics (1.0 mmol). Upon slow addition of NaBH4 (4.0 mmol), the color of the reaction mixture gradually changed to black within a few minutes, indicating the formation of palladium nanoparticles (TAPEHA-PdNPs). The reaction was stirred continuously for 1.5 h at room temperature and atmospheric pressure. After completion of the reaction, the catalyst was removed by filtration and the reaction solution was extracted with EtOAc (3 × 30 mL). The organic layers were combined, dried with MgSO4 and subsequently concentrated under vacuum.

References

[1] Turkish Journal of Chemistry, 2017, vol. 41, # 5, p. 784 - 792
[2] Catalysis Communications, 2015, vol. 67, p. 64 - 67

2-Amino-6-chloropyridine(45644-21-1)Related Product Information

• 2-Chloro-3-cyanopyridine
• ALTRENOGEST
• 4-Dimethylaminopyridine
• Glycine
• Pentachloropyridine
• 3-Aminopyridine
• 6-Aminocaproic acid
• Clopidol
• 3-Aminophenol
• 2-Aminopyridine
• 2-AMINO-4-CHLOROPYRIDINE
• 2-AMINO-3-CHLOROPYRIDINE
• 2-Amino-5-chloropyridine
• Edoxaban Impurity 12 (1R,2R,4S)
• tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate
• Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride
• Tris(hydroxymethyl)aminomethane
• Edoxaban Impurity 37