B7-33 2mg/5mg/10mg
B7-33 2mg/5mg/10mg Basic information
- Product Name:
- B7-33 2mg/5mg/10mg
- Synonyms:
-
- B7-33 2mg/5mg/10mg
- L-Leucinamide, L-valyl-L-isoleucyl-L-lysyl-L-leucyl-L-serylglycyl-L-arginyl-L-α-glutamyl-L-leucyl-L-valyl-L-arginyl-L-alanyl-L-glutaminyl-L-isoleucyl-L-alanyl-L-isoleucyl-L-serylglycyl-L-methionyl-L-seryl-L-threonyl-L-tryptophyl-L-seryl-L-lysyl-L-arginyl-L-seryl-
- CAS:
- 1818415-56-3
- MF:
- C131H229N41O36S
- MW:
- 2986.54
- Mol File:
- 1818415-56-3.mol
B7-33 2mg/5mg/10mg Chemical Properties
- Density
- 1.445±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
B7-33 2mg/5mg/10mg Usage And Synthesis
Description
B7-33 is a selective relaxin receptor 1 (RXFP1) agonist. It binds to RXFP1 and preferentially activates thepERK pathway over cAMP in cells (with RXFP1 expression).
Uses
B7-33 is a single-chain relaxin mimetic. B7-33 is a selective relaxin receptor 1 (RXFP1) agonist. B7-33 binds to RXFP1 and preferentially activates thepERK pathway over cAMP in cells (with RXFP1 expression). B7-33 is an anti-fibrotic agent. B7-33 has cardioprotective effects[1][2].
References
[1] Alam F, et al. The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy. Biomed Pharmacother. 2023 Apr;160:114370. DOI:10.1016/j.biopha.2023.114370
[2] Hossain MA, et al. A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1. Chem Sci. 2016 Jun 1;7(6):3805-3819. DOI:10.1039/c5sc04754d
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