5-HT Receptor Antagonists 5-HT Receptor agonists AChR antagonist Adrenergic Receptor agonists COX inhibitors Histamine Receptor Antagonists AChR agonist 5-HT Receptor modulators GluR agonist GluR antagonist 5-HT Receptor Inhibitor Adrenergic Receptor Antagonists Dopamine Receptor agonists Dopamine Receptor Antagonists Adrenergic Receptor Inhibitors AChR inhibitor Histamine Receptor Inhibitors Histamine Receptor agonists GABA Receptor agonists Opioid Receptor Antagonists CaMK inhibitors P2 Receptor Inhibitors P2 Receptor Antagonists AMPA and kainate receptors Beta Amyloid Inhibitors BACE inhibitors AChR modifiers Opioid Receptor agonists GluR modifiers GluR inhibitors
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Neuronal Signaling

5-HT Receptor Antagonists 5-HT Receptor agonists AChR antagonist Adrenergic Receptor agonists COX inhibitors Histamine Receptor Antagonists AChR agonist 5-HT Receptor modulators GluR agonist GluR antagonist 5-HT Receptor Inhibitor Adrenergic Receptor Antagonists Dopamine Receptor agonists Dopamine Receptor Antagonists Adrenergic Receptor Inhibitors AChR inhibitor Histamine Receptor Inhibitors Histamine Receptor agonists GABA Receptor agonists Opioid Receptor Antagonists CaMK inhibitors P2 Receptor Inhibitors P2 Receptor Antagonists AMPA and kainate receptors Beta Amyloid Inhibitors BACE inhibitors AChR modifiers Opioid Receptor agonists GluR modifiers GluR inhibitors
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The neural signals directly characterize the meaning of the human self. Studying the neural signal provides an approach for understanding and identifying the human body. Nerve signals share some similar features with other human biological signals, but also have some of its unique features. According to the research in neurobiology, nerve signal, resembling a pulse electric signal, has a frequency of generally around 1 kHz and can be as high as 10 kHz. For example, for a bundle of movement nerves that control muscle, when there is potential impulse signal arriving, the muscle fiber will have contractile response. The contraction strength, depending on the difference of the impulse frequency of nerve, will have the strength difference.

Learning and memory is an important area of research, not only because they dominate the normal human behavior, but also because it plays an important role in the development of nervous system diseases and disorders, which includes addiction, anxiety, depression, schizophrenia and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. At present, we haven’t achieved any significant efficacy for treatment aim to alleviate the learning and memory dysfunction. Therefore, pharmaceutical companies are quite interested in drug target which can improve the cognitive function including specific serotonin or serotonin receptors. What the serotonin system dominated are the specific brain regions which play an important regulatory role in the memory and learning processes.

This kind of neural domination is related the expression of a series of serotonin receptors (the drug target of serotonin). An important feature of the serotonin system is the universality of the neural domination of forebrain, which is originated from the discrete cluster located in raphe nuclei and the diversity of its receptors. The number of its receptors is up to 14, including 5-HT1A, 5 -HT4 and 5-HT6, and these receptors are all densely presented in the brain regions associated with learning and memory, and have impact on human cognitive impairment. Furthermore, selective agonist and/or antagonist compounds may take effect through acting on the three postsynaptic receptors to affect the clinical behavior patterns. These compounds, upon binding to the receptor, may also modulate neurotransmitter system instead of altering the release of 5-HT, thereby affecting the learning and memory.
GluR related chemicals are very popular. Ampakines, one kind of pyrrolidone derivatives, can act on α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor with its upregulation may enhance the synaptic plasticity. Early results of clinical studies have indicated ampakines may have a role in schizophrenia. Similarly, D-serine and D-cycloserine can stimulate the glycine co-agonist site located in the NMDA receptor which is insensitive to strychnine on, but also can enhance NMDA receptor activity. Such agents can improve the conditioned reflex of the clinical fear, and may also moderately improve the negative reactions and cognitive dysfunction in schizophrenia. Dopamine receptor is a hot filed in neurology and psychiatry. Receptors (D1, D2, D3, D4 and D5) are related the physiological functions of catecholamine neurotransmitter dopamine. Dopaminergic neurotransmission have been used to study Parkinson's disease, schizophrenia, bipolar disorder, Huntington's disease, attention deficit hyperactivity disorder and Tourette syndrome.The target of the neurological and psychiatric studies also include H3 receptor antagonists, COX receptors, γ- secretion, Glu receptor, adrenergic receptor, acetylcholine receptor, P-gp, P2 receptors and opioid receptors.

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Chemical Name:
Nepafenac
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C15H14N2O2
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Venlafaxine hydrochloride
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99300-78-4
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C17H28ClNO2
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C21H24ClNO3
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C19H25ClN2O
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ONDANSETRON HYDROCHLORIDE
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C18H20ClN3O
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C5H12N3O4P
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Clopidogrel Bisulfate
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C16H16ClNO2S.H2O4S
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C8H13NO2
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Synephrine hydrochloride
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5985-28-4
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C9H14ClNO2
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Roxatidine acetate hydrochloride
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C19H29ClN2O4
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Ketorolac tromethamine
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C19H24N2O6
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Asenapine Maleate
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C21H20ClNO5
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Orphenadrine citrate
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4682-36-4
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C24H31NO8
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Xylazine Hydrochloride
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23076-35-9
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C12H17ClN2S
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Solifenacin succinate
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242478-38-2
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C27H32N2O6
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Chemical Name:
Acebutolol hydrochloride
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C18H29ClN2O4
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Chemical Name:
(S)-Timolol maleate
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C17H28N4O7S
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Dexmedetomidine hydrochloride
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C13H17ClN2
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Chemical Name:
Eletriptan hydrobromide
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C22H27BrN2O2S
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Rizatriptan benzoate
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C22H25N5O2
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Chemical Name:
Silodosin
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C25H32F3N3O4
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Chemical Name:
Lafutidine
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118288-08-7
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C22H29N3O4S
Structure:
Chemical Name:
Levosulpiride
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23672-07-3
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C15H23N3O4S
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Chemical Name:
Fesoterodinefumarate
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286930-03-8
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C30H41NO7
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Chemical Name:
Histamine dihydrochloride
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56-92-8
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C5H11Cl2N3
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Chemical Name:
(R)-4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
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86347-15-1
MF:
C13H17ClN2
Structure:
Chemical Name:
Terazosin hydrochloride dihydrate
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70024-40-7
MF:
C19H30ClN5O6
Structure:
Chemical Name:
Ropinirole hydrochloride
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91374-20-8
MF:
C16H25ClN2O
Structure:
Chemical Name:
Atomoxetine hydrochloride
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82248-59-7
MF:
C17H22ClNO
Structure:
Chemical Name:
Detomidine hydrochloride
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90038-01-0
MF:
C12H15ClN2
Structure:
Chemical Name:
Donepezil Hydrochloride
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120011-70-3
MF:
C24H30ClNO3
Structure:
Chemical Name:
Tolfenamic acid
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13710-19-5
MF:
C14H12ClNO2
Structure:
Chemical Name:
Trospium chloride
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10405-02-4
MF:
C25H30ClNO3
Structure:
Chemical Name:
Mosapride citrate
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112885-42-4
MF:
C27H33ClFN3O10
Structure:
Chemical Name:
Otilonium bromide
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26095-59-0
MF:
C29H43BrN2O4
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Chemical Name:
Oxymetazoline hydrochloride
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2315-02-8
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C16H25ClN2O
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Chemical Name:
Duloxetine hydrochloride
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136434-34-9
MF:
C18H20ClNOS
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Chemical Name:
Tiotropium bromide hydrate
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139404-48-1
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C19H22BrNO4S2.H2O
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Chemical Name:
Cisatracurium besylate
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96946-42-8
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C53H72N2O12.2C6H5O3S
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Chemical Name:
Ivabradine hydrochloride
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148849-67-6
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C27H37ClN2O5
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Bethanechol
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590-63-6
MF:
C7H17ClN2O2
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Brimonidine Tartrate
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70359-46-5
MF:
C15H16BrN5O6
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Loxapine succinate salt
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27833-64-3
MF:
C22H24ClN3O5
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Chemical Name:
Blonanserin
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132810-10-7
MF:
C23H30FN3
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Chemical Name:
Varenicline tartrate
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375815-87-5
MF:
C17H19N3O6
Structure:
Chemical Name:
Paliperidone
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144598-75-4
MF:
C23H27FN4O3
Structure:
Chemical Name:
Memantine HCl
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41100-52-1
MF:
C12H22ClN
Structure:
Chemical Name:
Tianeptine sodium salt
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30123-17-2
MF:
C21H24ClN2NaO4S
Structure:
Chemical Name:
Triflusal
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322-79-2
MF:
C10H7F3O4
Structure:
Chemical Name:
Pergolide mesylate salt
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66104-23-2
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C20H30N2O3S2
Structure:
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Tropisetron hydrochloride
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105826-92-4
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C17H21ClN2O2
Structure:
Chemical Name:
Desvenlafaxine succinate
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386750-22-7
MF:
C20H31NO6
Structure:
Chemical Name:
SUCCINYLCHOLINE CHLORIDE DIHYDRATE
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6101-15-1
MF:
C14H34Cl2N2O6
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Chemical Name:
(R)-Baclofen
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69308-37-8
MF:
C10H12ClNO2
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Chemical Name:
1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-
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92206-54-7
MF:
C19H25NOS
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Chemical Name:
Bromfenac sodium
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91714-93-1
MF:
C15H11BrNNaO3
Structure:
Chemical Name:
(R)-5-HydroxyMethyl Tolterodine
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207679-81-0
MF:
C22H31NO2
Structure:
Chemical Name:
LY2811376
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1194044-20-6
MF:
C15H14F2N4S
Structure:
Chemical Name:
Rupatadine
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158876-82-5
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C26H26ClN3
Chemical Name:
APREPITANT (SUBSTANCE P antagonist)
Structure:
Chemical Name:
LUMIRACOXIB
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220991-20-8
MF:
C15H13ClFNO2
Structure:
Chemical Name:
MRS 2578
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711019-86-2
MF:
C20H20N6S4
Structure:
Chemical Name:
Prucalopride
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179474-81-8
MF:
C18H26ClN3O3
Structure:
Chemical Name:
Mirabegron
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223673-61-8
MF:
C21H24N4O2S
Structure:
Chemical Name:
VU 0357121
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433967-28-3
MF:
C17H17F2NO2
Structure:
Chemical Name:
ALMOTRIPTAN
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181183-52-8
MF:
C21H31N3O7S
Structure:
Chemical Name:
Ciproxifan
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184025-18-1
MF:
C16H18N2O2
Structure:
Chemical Name:
BRL 54443
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57477-39-1
MF:
C14H18N2O
Structure:
Chemical Name:
BUCLIZINE, DIHYDROCHLORIDE
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129-74-8
MF:
C28H35Cl3N2
Structure:
Chemical Name:
(R)-Tomoxetine
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83015-26-3
MF:
C17H21NO
Structure:
Chemical Name:
Rupatadine Fumarate
CAS:
182349-12-8
MF:
C26H26ClN3.C4H4O4
Structure:
Chemical Name:
10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid
CAS:
74711-43-6
MF:
C17H14O3S
Structure:
Chemical Name:
Prucalopride Succinate
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179474-85-2
MF:
C22H32ClN3O7
Structure:
Chemical Name:
Naratriptan Hydrochloride
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143388-64-1
MF:
C17H25N3O2S.ClH
Structure:
Chemical Name:
SB271046
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209481-20-9
MF:
C20H22ClN3O3S2
Structure:
Chemical Name:
Cariprazine hydrochloride
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1083076-69-0
MF:
C21H33Cl3N4O
Structure:
Chemical Name:
Fenazox
CAS:
61618-27-7
MF:
C15H16NNaO4
Structure:
Chemical Name:
LY2886721
CAS:
1262036-50-9
MF:
C18H16F2N4O2S
Structure:
Chemical Name:
Vilazodone Hydrochloride
CAS:
163521-08-2
MF:
C26H28ClN5O2
Structure:
Chemical Name:
Indacaterol Maleate
CAS:
753498-25-8
MF:
C28H32N2O7
Structure:
Chemical Name:
LasMiditan
CAS:
439239-90-4
MF:
C19H18F3N3O2
Structure:
Chemical Name:
BMY 7378 DIHYDROCHLORIDE
CAS:
21102-95-4
MF:
C22H32ClN3O3
Structure:
Chemical Name:
Naloxone hydrochloride dihydrate
CAS:
51481-60-8
MF:
C19H26ClNO6
Structure:
Chemical Name:
Pizotifen Malate
CAS:
5189-11-7
MF:
C23H27NO5S
Structure:
Chemical Name:
Nitenpyram
CAS:
150824-47-8
MF:
C11H15ClN4O2
Structure:
Chemical Name:
ROTIGOTINE
CAS:
99755-59-6
MF:
C19H25NOS
Structure:
Chemical Name:
Aclidinium bromide
CAS:
320345-99-1
MF:
C13H10BrN
Structure:
Chemical Name:
Indacaterol
CAS:
312753-06-3
MF:
C24H28N2O3
Structure:
Chemical Name:
O-Desmethylvenlafaxine
CAS:
93413-62-8
MF:
C16H25NO2
Chemical Name:
Dexmedetomidine
MF:
C13H16N2
Structure:
Chemical Name:
N-(5-CHLORO-2,4-DIMETHOXYPHENYL)-N'-(5-METHYL-3-ISOXAZOLYL)-UREA
CAS:
501925-31-1
MF:
C13H14ClN3O4
Structure:
Chemical Name:
Licofelone
CAS:
156897-06-2
MF:
C23H22ClNO2
Structure:
Chemical Name:
MPEP
CAS:
96206-92-7
MF:
C14H11N
Structure:
Chemical Name:
IFENPRODIL HEMITARTRATE
CAS:
23210-58-4
MF:
C25H33NO8
Structure:
Chemical Name:
Nebivolol hydrochloride
CAS:
152520-56-4
MF:
C22H26ClF2NO4
Structure:
Chemical Name:
JTC 801
CAS:
244218-51-7
MF:
C26H25N3O2.ClH
Structure:
Chemical Name:
Darifenacin hydrobromide
CAS:
133099-07-7
MF:
C28H31BrN2O2