Naratriptan Hydrochloride Chemical Properties

Melting point:

234-236°C

storage temp. 

-20°C Freezer

solubility 

H2O: ≥10mg/mL

form 

powder

color 

white to off-white

InChIKey

AWEZYKMQFAUBTD-UHFFFAOYSA-N

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

WGK Germany 

3

HS Code 

2935904000

Naratriptan Hydrochloride Usage And Synthesis

Description

Naramig was launched in Germany, Sweden and the UK for use in migraine. It is chemically available via a number of related synthetic routes all having about three steps starting from 5-bromoindole. It is a new serotonin 5-HT_1B/1D receptor antagonist with modest affinity for 5-HT_1a, and very weak affinity for 5-HT₃ receptors. It has little or no affinity for a wide range of non-serotonin receptors including a- and padrenoceptors, dopamine, neurokinin NK₁, and opiate receptors. It mediates vasoconstriction in cerebral vasculature (extra cerebral intracranial vessels), reduces neurogenic inflammation, and inhibits responses mediated by the trigeminal nerves. It has a 6- and 3-fold greater affinity for 5-HT_1B, and 5-HT_1D, receptors, respectively, than sumatriptan which translates to a 2-3 fold increase in potency. The reoccurance of headache was less compared to sumatriptan, zolmitriptan and rizatriptan. Naramig had no clinical effects on blood pressure or heart rate, had a long duration of action with very good tolerability, and has high oral bioavailability.

Chemical Properties

Beige Solid

Originator

Glaxo Wellcome (UK)

Uses

Naratriptan Hydrochloride is a triptan drug that is used for the treatment of migraine headaches. It is a selective 5-hydroxytryptamine1 receptor subtype agonist

Uses

Naratriptan Hydrochloride is a triptan drug and is used for the treatment of migraine headaches

Uses

laxative

brand name

Amerge (GlaxoSmithKline).

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